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Palanisamy S, Thirumalraj B, Chen SM, et al. A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine. Sci Rep. 2016;6:33599doi: 10.1038/srep33599.
Palanisamy, S., Thirumalraj, B., Chen, S. M., Wang, Y. T., Velusamy, V., & Ramaraj, S. K. (2016). A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine. Scientific reports, 633599. https://doi.org/10.1038/srep33599
Palanisamy, Selvakumar, et al. "A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine." Scientific reports vol. 6 (2016): 33599. doi: https://doi.org/10.1038/srep33599
Palanisamy S, Thirumalraj B, Chen SM, Wang YT, Velusamy V, Ramaraj SK. A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine. Sci Rep. 2016 Sep 21;6:33599. doi: 10.1038/srep33599. PMID: 27650697; PMCID: PMC5030524.
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Sci Rep. 2016 Sep 21;6:33599. doi: 10.1038/srep33599.

A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine.

Scientific reports

Selvakumar Palanisamy, Balamurugan Thirumalraj, Shen-Ming Chen, Yi-Ting Wang, Vijayalakshmi Velusamy, Sayee Kannan Ramaraj

Affiliations

  1. Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan ROC.
  2. Division of Electrical and Electronic Engineering, School of Engineering, Manchester Metropolitan University, Manchester M1 5GD, United Kingdom.
  3. PG &Research department of Chemistry, Thiagarajar College, Madurai, 625009, India.

PMID: 27650697 PMCID: PMC5030524 DOI: 10.1038/srep33599

Abstract

We report a novel and sensitive amperometric sensor for chlorpromazine (CPZ) based on reduced graphene oxide (RGO) and polydopamine (PDA) composite modified glassy carbon electrode. The RGO@PDA composite was prepared by electrochemical reduction of graphene oxide (GO) with PDA. The RGO@PDA composite modified electrode shows an excellent electro-oxidation behavior to CPZ when compared with other modified electrodes such as GO, RGO and GO@PDA. Amperometric i-t method was used for the determination of CPZ. Amperometry result shows that the RGO@PDA composite detects CPZ in a linear range from 0.03 to 967.6 μM. The sensor exhibits a low detection limit of 0.0018 μM with the analytical sensitivity of 3.63 ± 0.3 μAμM(-1 )cm(-2). The RGO@PDA composite shows its high selectivity towards CPZ in the presence of potentially interfering drugs such as metronidazole, phenobarbital, chlorpheniramine maleate, pyridoxine and riboflavin. In addition, the fabricated RGO@PDA modified electrode showed an appropriate recovery towards CPZ in the pharmaceutical tablets.

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