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Fanthome B, Bharadwaj R, Suryanarayana KM. Parathyroid Neoplasms: The Army Hospital (Research & Referral) Experience. Med J Armed Forces India. 2011;62(4):312-5doi: 10.1016/S0377-1237(06)80094-8.
Fanthome, B., Bharadwaj, R., & Suryanarayana, K. M. (2006). Parathyroid Neoplasms: The Army Hospital (Research & Referral) Experience. Medical journal, Armed Forces India, 62(4), 312-5. https://doi.org/10.1016/S0377-1237(06)80094-8
Fanthome, B, et al. "Parathyroid Neoplasms: The Army Hospital (Research & Referral) Experience." Medical journal, Armed Forces India vol. 62,4 (2006): 312-5. doi: https://doi.org/10.1016/S0377-1237(06)80094-8
Fanthome B, Bharadwaj R, Suryanarayana KM. Parathyroid Neoplasms: The Army Hospital (Research & Referral) Experience. Med J Armed Forces India. 2006 Oct;62(4):312-5. doi: 10.1016/S0377-1237(06)80094-8. Epub 2011 Jul 21. PMID: 27688529; PMCID: PMC5034197.
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Med J Armed Forces India. 2006 Oct;62(4):312-5. doi: 10.1016/S0377-1237(06)80094-8. Epub 2011 Jul 21.

Parathyroid Neoplasms: The Army Hospital (Research & Referral) Experience.

Medical journal, Armed Forces India

B Fanthome, R Bharadwaj, K M Suryanarayana

Affiliations

  1. Senior Advisor (Surgery & Oncosurgery), INHS Asvini, Mumbai.
  2. Reader (Pathology & Oncopathology), Armed Forces Medical College, Pune.
  3. Consultant (Medicine and Endocrinology), Command Hospital (Air Force), Bangalore.

PMID: 27688529 PMCID: PMC5034197 DOI: 10.1016/S0377-1237(06)80094-8

Abstract

BACKGROUND: Neoplasms of the parathyroid are common but parathyroid carcinoma is exceptionally rare. In contrast to most other malignant endocrine tumours that are usually less hormonally active, malignant parathyroid tumours are hyper functional. Malignant parathyroid tumours pose a diagnostic dilemma for the pathologist.

OBJECTIVE: To study the clinicopathological profile of a case series of parathyroid neoplasms and determine features which facilitate a malignant diagnosis.

METHODS: A retrospective analysis of seven cases of surgically treated parathyroid tumours over a three-year period at a single centre was done. Clinical, haematological, biochemical, and radiological data was accrued from medical records. The histopathology slides were reviewed along with the clinicopathological profile in an attempt to delineate markers of malignancy.

RESULTS: Patients ranged from 30 to 58 years of age. Males and females were approximately equal. Weakness and bone pain were the commonest presenting symptoms. Over 50% had significant hypercalcaemia and all had elevated serum parathormone. Clinically apparent mass was seen in only one. All tumours were successfully localised using CT scan and MRI. Thick fibrous capsule and broad septal fibrosis was seen in both the carcinomas; these were thin in the adenomas. Mitotic counts of 1-3 per high power field (HPF), capsular invasion and nodal metastasis were noted in the malignant tumours.

CONCLUSION: Elevated serum calcium and parathormone values point to a parathyroid neoplasm. Current imaging modalities are successful in localising the tumour preoperatively. Markedly elevated serum calcium, broad fibrous bands, mitotic counts and capsular invasion are indicators of malignancy.

Keywords: Adenoma; Carcinoma; Parathyroid

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