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Howard J, Trevick S, Younger DS. Epidemiology of Multiple Sclerosis. Neurol Clin. 2016;34(4):919-939doi: 10.1016/j.ncl.2016.06.016.
Howard, J., Trevick, S., & Younger, D. S. (2016). Epidemiology of Multiple Sclerosis. Neurologic clinics, 34(4), 919-939. https://doi.org/10.1016/j.ncl.2016.06.016
Howard, Jonathan, et al. "Epidemiology of Multiple Sclerosis." Neurologic clinics vol. 34,4 (2016): 919-939. doi: https://doi.org/10.1016/j.ncl.2016.06.016
Howard J, Trevick S, Younger DS. Epidemiology of Multiple Sclerosis. Neurol Clin. 2016 Nov;34(4):919-939. doi: 10.1016/j.ncl.2016.06.016. Epub 2016 Aug 18. PMID: 27720001.
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Neurol Clin. 2016 Nov;34(4):919-939. doi: 10.1016/j.ncl.2016.06.016. Epub 2016 Aug 18.

Epidemiology of Multiple Sclerosis.

Neurologic clinics

Jonathan Howard, Stephen Trevick, David S Younger

Affiliations

  1. Division of Neuroepidemiology, Department of Neurology, Comprehensive Care Center, New York University, New York, NY, USA. Electronic address: [email protected].
  2. New York University Langone Medical Center, New York, NY, USA.
  3. Division of Neuroepidemiology, Department of Neurology, New York University School of Medicine, College of Global Public Health, New York University, New York, NY, USA.

PMID: 27720001 DOI: 10.1016/j.ncl.2016.06.016

Abstract

The epidemiology of multiple sclerosis (MS) includes a consideration of genetic and environmental factors. Comparative studies of different populations have revealed prevalence and incidence rates that vary with geography and ethnicity. With a prevalence ranging from 2 per 100,000 in Japan to greater than 100 per 100,000 in Northern Europe and North America, the burden of MS is similarly unevenly influenced by longevity and comorbid disorders. Well-powered genome-wide association studies have investigated the genetic substrate of MS, providing insight into autoimmune mechanisms involved in the etiopathogenesis of MS and elucidating possible avenues of biological treatment.

Copyright © 2016 Elsevier Inc. All rights reserved.

Keywords: Multiple sclerosis; Neuroepidemiology; Public health

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