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Wang SM, Han C, Lee SJ, et al. Second Generation Antipsychotics in the Treatment of Major Depressive Disorder: An Update. Chonnam Med J. 2016;52(3):159-72doi: 10.4068/cmj.2016.52.3.159.
Wang, S. M., Han, C., Lee, S. J., Jun, T. Y., Patkar, A. A., Masand, P. S., & Pae, C. U. (2016). Second Generation Antipsychotics in the Treatment of Major Depressive Disorder: An Update. Chonnam medical journal, 52(3), 159-72. https://doi.org/10.4068/cmj.2016.52.3.159
Wang, Sheng-Min, et al. "Second Generation Antipsychotics in the Treatment of Major Depressive Disorder: An Update." Chonnam medical journal vol. 52,3 (2016): 159-72. doi: https://doi.org/10.4068/cmj.2016.52.3.159
Wang SM, Han C, Lee SJ, Jun TY, Patkar AA, Masand PS, Pae CU. Second Generation Antipsychotics in the Treatment of Major Depressive Disorder: An Update. Chonnam Med J. 2016 Sep;52(3):159-72. doi: 10.4068/cmj.2016.52.3.159. Epub 2016 Sep 23. PMID: 27689026; PMCID: PMC5040765.
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Chonnam Med J. 2016 Sep;52(3):159-72. doi: 10.4068/cmj.2016.52.3.159. Epub 2016 Sep 23.

Second Generation Antipsychotics in the Treatment of Major Depressive Disorder: An Update.

Chonnam medical journal

Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Tae-Youn Jun, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae

Affiliations

  1. Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.; International Health Care Center, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
  2. Department of Psychiatry, College of Medicine, Korea University, Korea.
  3. Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
  4. Department of Psychiatry and Behavioural Sciences, Duke University Medical Center, Durham, NC, USA.
  5. Global Medical Education, New York, NY, USA.
  6. Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.; Department of Psychiatry and Behavioural Sciences, Duke University Medical Center, Durham, NC, USA.

PMID: 27689026 PMCID: PMC5040765 DOI: 10.4068/cmj.2016.52.3.159

Abstract

Less than one third of patients who suffer from major depressive disorder (MDD) report remission following antidepressant treatments requiring more diverse treatment approaches. Augmentation of second generation antipsychotics (SGAs) has been increasingly recognized as an important treatment option. The authors have previously provided a comprehensive review of SGAs for the treatment of MDD in 2013. Since then, numerous additional clinical trials have been conducted to investigate diverse issues regarding the utility of SGAs in MDD. Moreover, a new SGA, brexpiprazole, was recently approved by the Food and Drug Administration in July 2015 for the treatment of MDD as an augmentation agent to antidepressants. Thus, the aim of this study was to provide a concise update of all the available SGAs for the treatment of MDD, in particular on the additional clinical trials which have been published since 2013.

Keywords: Antidepressive Agents; Antipsychotic Agents; Clinical Trial; Depressive Disorder; Depressive Disorder, Treatment-Resistant

Conflict of interest statement

None declared.

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