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Naseri M, Sarvari GR, Esmaeeli M, et al. High doses of oral folate and sublingual vitamin B12 in dialysis patients with hyperhomocysteinemia. J Renal Inj Prev. 2016;5(3):134-9doi: 10.15171/jrip.2016.28.
Naseri, M., Sarvari, G. R., Esmaeeli, M., Azarfar, A., Rasouli, Z., Moeenolroayaa, G., Jahanshahi, S., Farhadi, S., Heydari, Z., & Sagheb-Taghipoor, N. (2016). High doses of oral folate and sublingual vitamin B12 in dialysis patients with hyperhomocysteinemia. Journal of renal injury prevention, 5(3), 134-9. https://doi.org/10.15171/jrip.2016.28
Naseri, Mitra, et al. "High doses of oral folate and sublingual vitamin B12 in dialysis patients with hyperhomocysteinemia." Journal of renal injury prevention vol. 5,3 (2016): 134-9. doi: https://doi.org/10.15171/jrip.2016.28
Naseri M, Sarvari GR, Esmaeeli M, Azarfar A, Rasouli Z, Moeenolroayaa G, Jahanshahi S, Farhadi S, Heydari Z, Sagheb-Taghipoor N. High doses of oral folate and sublingual vitamin B12 in dialysis patients with hyperhomocysteinemia. J Renal Inj Prev. 2016 Aug 06;5(3):134-9. doi: 10.15171/jrip.2016.28. eCollection 2016. PMID: 27689109; PMCID: PMC5039999.
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J Renal Inj Prev. 2016 Aug 06;5(3):134-9. doi: 10.15171/jrip.2016.28. eCollection 2016.

High doses of oral folate and sublingual vitamin B12 in dialysis patients with hyperhomocysteinemia.

Journal of renal injury prevention

Mitra Naseri, Gholam-Reza Sarvari, Mohammad Esmaeeli, Anoush Azarfar, Zahra Rasouli, Giti Moeenolroayaa, Shohre Jahanshahi, Simin Farhadi, Zohreh Heydari, Narges Sagheb-Taghipoor

Affiliations

  1. Hemodialysis Section, Dr. Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 27689109 PMCID: PMC5039999 DOI: 10.15171/jrip.2016.28

Abstract

INTRODUCTION: Folic acid and vitamin B12, alone or in combination have been used to reduce homocysteine (Hcy) levels in dialysis patients.

OBJECTIVES: We aimed to assess the efficacy of high doses of oral folate and vitamin B12 in reducing plasma Hcy levels after a 12-week treatment.

PATIENTS AND METHODS: Thirty-two dialysis patients aged 10-324 months screened for hyperhomocysteinuria. Then cases with hyperhomocysteinemia received oral folate 10 mg/day with sublingual methylcobalamin 1 mg/day for 12 weeks. In pre- and post-intervention phases plasma Hcy concentration, serum folate, and vitamin B12 levels were measured. Changes in plasma Hcy, serum folate, and vitamin B12 concentrations were analyzed by paired t tests, and P values < 0.05 were considered significant.

RESULTS: Eighteen (56.2%) patients had hyperhomocysteinuria. Vitamin B12 and folate levels were normal or high in all cases. Two patients were lost due to transplant or irregular drugs consumption. Plasma Hcy levels were reduced in all, and reached normal values in 50%. A statistically significant differences between first Hcy levels with levels after intervention was found (95% CI, 5.1-8.9, P = 0.0001).

CONCLUSION: Oral folate 10 mg/day in combination with sublingual vitamin B12, 1 mg/day can be considered as a favorable treatment for hyperhomocysteinemia in dialysis patients.

Keywords: Dialysis; Folate; Hyperhomocysteinemia; Vitamin B12

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