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Gaston CL, Grimer RJ, Parry M, et al. Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone. Clin Sarcoma Res. 2016;6(1):15doi: 10.1186/s13569-016-0056-0.
Gaston, C. L., Grimer, R. J., Parry, M., Stacchiotti, S., Dei Tos, A. P., Gelderblom, H., Ferrari, S., Baldi, G. G., Jones, R. L., Chawla, S., Casali, P., LeCesne, A., Blay, J. Y., Dijkstra, S. P., Thomas, D. M., & Rutkowski, P. (2016). Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone. Clinical sarcoma research, 6(1), 15. https://doi.org/10.1186/s13569-016-0056-0
Gaston, Czar Louie, et al. "Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone." Clinical sarcoma research vol. 6,1 (2016): 15. doi: https://doi.org/10.1186/s13569-016-0056-0
Gaston CL, Grimer RJ, Parry M, Stacchiotti S, Dei Tos AP, Gelderblom H, Ferrari S, Baldi GG, Jones RL, Chawla S, Casali P, LeCesne A, Blay JY, Dijkstra SP, Thomas DM, Rutkowski P. Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone. Clin Sarcoma Res. 2016 Sep 14;6(1):15. doi: 10.1186/s13569-016-0056-0. eCollection 2016. PMID: 27651889; PMCID: PMC5022265.
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Clin Sarcoma Res. 2016 Sep 14;6(1):15. doi: 10.1186/s13569-016-0056-0. eCollection 2016.

Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone.

Clinical sarcoma research

Czar Louie Gaston, Robert J Grimer, Michael Parry, Silvia Stacchiotti, Angelo Paolo Dei Tos, Hans Gelderblom, Stefano Ferrari, Giacomo G Baldi, Robin L Jones, Sant Chawla, Paolo Casali, Axel LeCesne, Jean-Yves Blay, Sander P D Dijkstra, David M Thomas, Piotr Rutkowski

Affiliations

  1. Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Birmingham, B31 2AP UK.
  2. Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  3. Department of Anatomic Pathology, General Hospital of Treviso, Treviso, Italy.
  4. Leiden University Medical Center, Leiden, Netherlands.
  5. Department of Oncology, Rizzoli Institute, Bologna, Italy.
  6. Department of Cancer Medicine, S. Stefano Civil Hospital, Prato, Italy.
  7. University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA USA ; Royal Marsden Hospital, London, UK.
  8. Sarcoma Oncology Center, Santa Monica, CA USA.
  9. Institut Gustave Roussy, Villejuif, France.
  10. Centre Leon Berard, Lyon, France.
  11. Garvan Institute of Medical Research, Sydney, Australia.
  12. Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Center and Institute of Oncology, Warsaw, Poland.

PMID: 27651889 PMCID: PMC5022265 DOI: 10.1186/s13569-016-0056-0

Abstract

Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosumab has also been used pre-operatively to downstage tumours with large soft tissue extension to allow for less morbid surgery. The role of Denosumab for conventional limb GCT of bone is yet to be defined. Further studies are required to determine whether local recurrence rates will be decreased with the adjuvant use of Denosumab along with surgery. The long term use and toxicity of this agent is unknown as is the proportion of patients with primary or secondary resistance. It is advised that complicated cases of GCT requiring Denosumab treatment should be referred and followed up at expert centres. Collaborative studies involving further clinical trials and rigorous data collection are strongly recommended to identify the optimum use of this drug.

Keywords: Denosumab; Giant cell tumor of bone; Inoperable; Neoadjuvant; Safety; Surgery

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