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Pezzi M, Giglio AM, Scozzafava A, et al. Spider Bite: A Rare Case of Acute Necrotic Arachnidism with Rapid and Fatal Evolution. Case Rep Emerg Med. 2016;2016:7640789doi: 10.1155/2016/7640789.
Pezzi, M., Giglio, A. M., Scozzafava, A., Filippelli, O., Serafino, G., & Verre, M. (2016). Spider Bite: A Rare Case of Acute Necrotic Arachnidism with Rapid and Fatal Evolution. Case reports in emergency medicine, 20167640789. https://doi.org/10.1155/2016/7640789
Pezzi, Mario, et al. "Spider Bite: A Rare Case of Acute Necrotic Arachnidism with Rapid and Fatal Evolution." Case reports in emergency medicine vol. 2016 (2016): 7640789. doi: https://doi.org/10.1155/2016/7640789
Pezzi M, Giglio AM, Scozzafava A, Filippelli O, Serafino G, Verre M. Spider Bite: A Rare Case of Acute Necrotic Arachnidism with Rapid and Fatal Evolution. Case Rep Emerg Med. 2016;2016:7640789. doi: 10.1155/2016/7640789. Epub 2016 Aug 29. PMID: 27651958; PMCID: PMC5019911.
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Case Rep Emerg Med. 2016;2016:7640789. doi: 10.1155/2016/7640789. Epub 2016 Aug 29.

Spider Bite: A Rare Case of Acute Necrotic Arachnidism with Rapid and Fatal Evolution.

Case reports in emergency medicine

Mario Pezzi, Anna Maria Giglio, Annamaria Scozzafava, Orazio Filippelli, Giuseppe Serafino, Mario Verre

Affiliations

  1. Anaesthesia and Intensive Care Unit, General Hospital "Pugliese-Ciaccio", Viale Pio X, 88100 Catanzaro, Italy.

PMID: 27651958 PMCID: PMC5019911 DOI: 10.1155/2016/7640789

Abstract

The spider bites are quite frequent and often resolve quickly without leaving outcomes; only some species are capable of causing necrotic and systematic lesions in humans. Among them, we should mention the genus Loxosceles. The venom released from the spider bite of Loxosceles species is composed of proteins, enzymes, and nonenzymatic polypeptides. The phospholipase D family was identified as the active component of the venom. This family of enzymes is responsible for the local and systemic effects observed in loxoscelism. Phospholipases D interact with cell membranes triggering alterations which involve the complement system and activation of neutrophils and they cause the dermonecrotic skin lesions and systemic effects. We describe a fatal case of acute intoxication caused by a spider bite probably belonging to the species Loxosceles. The initial lesion was localized to a finger of a hand. Clinical course was worsening with deep necrotic lesions on limb, shock, hemolysis, acute kidney failure, and disseminated intravascular coagulation. All therapies were ineffective. This is the first fatal case described in Europe.

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