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Zagorianou A, Marougkas M, Drakos SG, et al. The effect of long-term amiodarone administration on myocardial fibrosis and evolution of left ventricular remodeling in a porcine model of ischemic cardiomyopathy. Springerplus. 2016;5(1):1568doi: 10.1186/s40064-016-3249-3.
Zagorianou, A., Marougkas, M., Drakos, S. G., Diakos, N., Konstantopoulos, P., Perrea, D. N., Anastasiou-Nana, M., & Malliaras, K. (2016). The effect of long-term amiodarone administration on myocardial fibrosis and evolution of left ventricular remodeling in a porcine model of ischemic cardiomyopathy. SpringerPlus, 5(1), 1568. https://doi.org/10.1186/s40064-016-3249-3
Zagorianou, Anastasia, et al. "The effect of long-term amiodarone administration on myocardial fibrosis and evolution of left ventricular remodeling in a porcine model of ischemic cardiomyopathy." SpringerPlus vol. 5,1 (2016): 1568. doi: https://doi.org/10.1186/s40064-016-3249-3
Zagorianou A, Marougkas M, Drakos SG, Diakos N, Konstantopoulos P, Perrea DN, Anastasiou-Nana M, Malliaras K. The effect of long-term amiodarone administration on myocardial fibrosis and evolution of left ventricular remodeling in a porcine model of ischemic cardiomyopathy. Springerplus. 2016 Sep 15;5(1):1568. doi: 10.1186/s40064-016-3249-3. eCollection 2016. PMID: 27652141; PMCID: PMC5023647.
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Springerplus. 2016 Sep 15;5(1):1568. doi: 10.1186/s40064-016-3249-3. eCollection 2016.

The effect of long-term amiodarone administration on myocardial fibrosis and evolution of left ventricular remodeling in a porcine model of ischemic cardiomyopathy.

SpringerPlus

Anastasia Zagorianou, Meletios Marougkas, Stavros G Drakos, Nikolaos Diakos, Panagiotis Konstantopoulos, Despina N Perrea, Maria Anastasiou-Nana, Konstantinos Malliaras

Affiliations

  1. 3rd Department of Cardiology, University of Athens School of Medicine, Laiko Hospital, 67 Mikras Asias Street, 11 527 Athens, Greece.
  2. Laboratory for Experimental Surgery and Surgical Research "N.S. Christeas", University of Athens School of Medicine, Athens, Greece.

PMID: 27652141 PMCID: PMC5023647 DOI: 10.1186/s40064-016-3249-3

Abstract

Amiodarone is effective in suppressing arrhythmias in heart failure patients. We investigated the effect of long-term amiodarone administration on myocardial fibrosis and left ventricular (LV) remodeling in a porcine model of ischemic cardiomyopathy. Eighteen infarcted farm pigs were randomized to receive long-term amiodarone administration for 3 months (n = 9) or conventional follow-up (n = 9). Evolution of LV remodeling over 3 months post-myocardial infarction was examined at tissue level (myocyte size, myocardial fibrosis and vascular density assessed by whole-field digital histopathology), organ level (LV structure and function assessed by echocardiography), and systemic level (BNP and MMP-9 levels). Long-term administration of the standard anti-arrhythmic doses of amiodarone was not associated with adverse effects on myocardial fibrosis and other features of adverse cardiac remodeling. This favorable safety profile suggests that long-term anti-arrhythmic therapy with amiodarone warrants further clinical investigation in the subpopulation of heart failure patients with significantly increased burden of arrhythmias.

Keywords: Amiodarone; Cardiac remodeling; Heart failure; Myocardial fibrosis; Myocardial infarction

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