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Bekos C, Zimmermann M, Unger L, et al. Non-professional marathon running: RAGE axis and ST2 family changes in relation to open-window effect, inflammation and renal function. Sci Rep. 2016;6:32315doi: 10.1038/srep32315.
Bekos, C., Zimmermann, M., Unger, L., Janik, S., Hacker, P., Mitterbauer, A., Koller, M., Fritz, R., Gäbler, C., Kessler, M., Nickl, S., Didcock, J., Altmann, P., Haider, T., Roth, G., Klepetko, W., Ankersmit, H. J., & Moser, B. (2016). Non-professional marathon running: RAGE axis and ST2 family changes in relation to open-window effect, inflammation and renal function. Scientific reports, 632315. https://doi.org/10.1038/srep32315
Bekos, Christine, et al. "Non-professional marathon running: RAGE axis and ST2 family changes in relation to open-window effect, inflammation and renal function." Scientific reports vol. 6 (2016): 32315. doi: https://doi.org/10.1038/srep32315
Bekos C, Zimmermann M, Unger L, Janik S, Hacker P, Mitterbauer A, Koller M, Fritz R, Gäbler C, Kessler M, Nickl S, Didcock J, Altmann P, Haider T, Roth G, Klepetko W, Ankersmit HJ, Moser B. Non-professional marathon running: RAGE axis and ST2 family changes in relation to open-window effect, inflammation and renal function. Sci Rep. 2016 Sep 22;6:32315. doi: 10.1038/srep32315. PMID: 27653273; PMCID: PMC5032027.
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Sci Rep. 2016 Sep 22;6:32315. doi: 10.1038/srep32315.

Non-professional marathon running: RAGE axis and ST2 family changes in relation to open-window effect, inflammation and renal function.

Scientific reports

Christine Bekos, Matthias Zimmermann, Lukas Unger, Stefan Janik, Philipp Hacker, Andreas Mitterbauer, Michael Koller, Robert Fritz, Christian Gäbler, Mario Kessler, Stefanie Nickl, Jessica Didcock, Patrick Altmann, Thomas Haider, Georg Roth, Walter Klepetko, Hendrik Jan Ankersmit, Bernhard Moser

Affiliations

  1. Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University Vienna, Austria.
  2. Department of Obstetrics and Gynaecology, Division of Gynaecology and Gynecological Oncology, Medical University Vienna, Austria.
  3. Sportordination, Alserstraße 27/1/6, Vienna, Austria.
  4. Austrian Red Cross, Nottendorfer Gasse 21, 1030 Wien, Austria.
  5. Department of Surgery, Division of Plastic and Reconstructive Surgery, Medical University Vienna, Austria.
  6. Department of Trauma Surgery, Medical University Vienna, Austria.
  7. Department of Anesthesia, Critical Care and Pain Medicine, Medical University Vienna, Austria.
  8. Department of Surgery, Division of Thoracic Surgery, Medical University Vienna, Austria.

PMID: 27653273 PMCID: PMC5032027 DOI: 10.1038/srep32315

Abstract

Conflicting data exist on the relevance of marathon (M) and half marathon (HM) running for health. The number of non-professional athletes finishing M and HM events is steadily growing. In order to investigate molecular changes occurring in amateur athletes, we enrolled 70 non-professional runners finishing a single M (34) or HM (36) event at baseline, the finish line and during recovery, and 30 controls. The measurement of the Receptor for Advanced Glycation Endproducts, Interleukin 1 receptor antagonist, ST2 and cytokeratin 18 was combined with molecules measured during clinical routine. Results were analyzed in the light of blood cell analysis, lactate measurements, correction for changes in plasma volume and body composition assessments. There were intrinsic differences in body mass index, abdominal body fat percentage and training time between M and HM runners. C-reactive protein changes in M and HM runners. While soluble RAGE, AGEs and ST2 increased immediately after the race in HM runners, HMGB1 increased in HM and M after the race and declined to baseline after a recovery period. We give insights into the regulation of various molecules involved in physical stress reactions and their possible implications for the cardiovascular system or renal function.

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