Display options
Cite
Krishnan A, Chagani S, Rohl AJ. Preoperative Testosterone Therapy Prior to Surgical Correction of Hypospadias: A Review of the Literature. Cureus. 2016;8(7):e677doi: 10.7759/cureus.677.
Krishnan, A., Chagani, S., & Rohl, A. J. (2016). Preoperative Testosterone Therapy Prior to Surgical Correction of Hypospadias: A Review of the Literature. Cureus, 8(7), e677. https://doi.org/10.7759/cureus.677
Krishnan, Arvind, et al. "Preoperative Testosterone Therapy Prior to Surgical Correction of Hypospadias: A Review of the Literature." Cureus vol. 8,7 (2016): e677. doi: https://doi.org/10.7759/cureus.677
Krishnan A, Chagani S, Rohl AJ. Preoperative Testosterone Therapy Prior to Surgical Correction of Hypospadias: A Review of the Literature. Cureus. 2016 Jul 08;8(7):e677. doi: 10.7759/cureus.677. PMID: 27551655; PMCID: PMC4977217.
Copy Download .nbib Format: NLM
Share it on

Cureus. 2016 Jul 08;8(7):e677. doi: 10.7759/cureus.677.

Preoperative Testosterone Therapy Prior to Surgical Correction of Hypospadias: A Review of the Literature.

Cureus

Arvind Krishnan, Sean Chagani, Austin J Rohl

Affiliations

  1. University of Central Florida College of Medicine.

PMID: 27551655 PMCID: PMC4977217 DOI: 10.7759/cureus.677

Abstract

Hypospadias is a congenital anomaly of the male urethra that causes significant morbidity in the pediatric male population. The mainstay of treatment is hypospadias repair surgery. However, given the common co-occurrence of microphallus in these patients, surgery remains difficult without adequate tissue for proper reconstruction of the urethra. The use of preoperative testosterone therapy, parenterally or topically, has been a topic of study for several years in urologic literature. This literature review aims to summarize the different studies that have been conducted to address whether preoperative testosterone therapy is beneficial, inconsequential, or detrimental to the surgical and cosmetic outcomes of hypospadias repair as well as to address the differences in routes of administration.

Keywords: androgen therapy; hypospadias; male urethra; microphallus; testosterone therapy; urology

References

  1. Ann Surg. 1991 Jun;213(6):620-5; discussion 625-6 - PubMed
  2. Urol Clin North Am. 2004 Aug;31(3):445-60, viii - PubMed
  3. J Pediatr Surg. 2003 Feb;38(2):221-3 - PubMed
  4. J Urol. 2008 Feb;179(2):684-8 - PubMed
  5. J Urol. 1998 Sep;160(3 Pt 2):1134-6; discussion 1137 - PubMed
  6. J Urol. 1998 Sep;160(3 Pt 2):1108-15; discussion 1137 - PubMed
  7. J Pediatr Urol. 2015 Jun;11(3):143.e1-6 - PubMed
  8. Pediatrics. 2005 Apr;115(4):e495-9 - PubMed
  9. Pediatr Surg Int. 2009 Jan;25(1):57-9 - PubMed
  10. Pediatrics. 1997 Nov;100(5):831-4 - PubMed
  11. J Urol. 1994 Jan;151(1):191-6 - PubMed
  12. Pediatr Surg Int. 2002 Mar;18(2-3):142-6 - PubMed
  13. J Pathol. 2009 Jan;217(1):73-82 - PubMed
  14. J Urol. 1987 Oct;138(4 Pt 2):1077-8 - PubMed
  15. Pediatrics. 1996 Apr;97(4):590-4 - PubMed
  16. Pediatr Surg Int. 2003 Apr;19(1-2):82-4 - PubMed
  17. BJU Int. 1999 Jun;83(9):1032-8 - PubMed
  18. J Urol. 2011 Jun;185(6 Suppl):2474-8 - PubMed
  19. Urol Ann. 2011 Sep;3(3):138-40 - PubMed
  20. J Urol. 1999 Oct;162(4):1435-9 - PubMed
  21. J Pediatr Surg. 2006 Mar;41(3):463-72 - PubMed
  22. Eur Urol. 1982;8(4):201-3 - PubMed
  23. J Urol. 2002 Oct;168(4 Pt 2):1723-6; discussion 1726 - PubMed
  24. Korean J Urol. 2012 Oct;53(10):711-5 - PubMed

Publication Types