Display options
Cite
Vega JN, Zurkovsky L, Albert K, et al. Altered Brain Connectivity in Early Postmenopausal Women with Subjective Cognitive Impairment. Front Neurosci. 2016;10:433doi: 10.3389/fnins.2016.00433.
Vega, J. N., Zurkovsky, L., Albert, K., Melo, A., Boyd, B., Dumas, J., Woodward, N., McDonald, B. C., Saykin, A. J., Park, J. H., Naylor, M., & Newhouse, P. A. (2016). Altered Brain Connectivity in Early Postmenopausal Women with Subjective Cognitive Impairment. Frontiers in neuroscience, 10433. https://doi.org/10.3389/fnins.2016.00433
Vega, Jennifer N, et al. "Altered Brain Connectivity in Early Postmenopausal Women with Subjective Cognitive Impairment." Frontiers in neuroscience vol. 10 (2016): 433. doi: https://doi.org/10.3389/fnins.2016.00433
Vega JN, Zurkovsky L, Albert K, Melo A, Boyd B, Dumas J, Woodward N, McDonald BC, Saykin AJ, Park JH, Naylor M, Newhouse PA. Altered Brain Connectivity in Early Postmenopausal Women with Subjective Cognitive Impairment. Front Neurosci. 2016 Sep 23;10:433. doi: 10.3389/fnins.2016.00433. eCollection 2016. PMID: 27721740; PMCID: PMC5034407.
Copy Download .nbib Format: NLM
Share it on

Front Neurosci. 2016 Sep 23;10:433. doi: 10.3389/fnins.2016.00433. eCollection 2016.

Altered Brain Connectivity in Early Postmenopausal Women with Subjective Cognitive Impairment.

Frontiers in neuroscience

Jennifer N Vega, Lilia Zurkovsky, Kimberly Albert, Alyssa Melo, Brian Boyd, Julie Dumas, Neil Woodward, Brenna C McDonald, Andrew J Saykin, Joon H Park, Magdalena Naylor, Paul A Newhouse

Affiliations

  1. Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University School of Medicine Nashville, TN, USA.
  2. Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont College of Medicine Burlington, VT, USA.
  3. Department of Radiology and Imaging Sciences and the Indiana Alzheimer Disease Center, Indiana University School of Medicine Indianapolis, IN, USA.
  4. Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University School of MedicineNashville, TN, USA; Department of Psychiatry, Jeju National University School of MedicineJejudo, South Korea.
  5. Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University School of MedicineNashville, TN, USA; Department of Veterans Affairs, Geriatric Research, Education, and Clinical Center, Tennessee Valley Health SystemNashville, TN, USA.

PMID: 27721740 PMCID: PMC5034407 DOI: 10.3389/fnins.2016.00433

Abstract

Cognitive changes after menopause are a common complaint, especially as the loss of estradiol at menopause has been hypothesized to contribute to the higher rates of dementia in women. To explore the neural processes related to subjective cognitive complaints, this study examined resting state functional connectivity in 31 postmenopausal women (aged 50-60) in relationship to cognitive complaints following menopause. A cognitive complaint index was calculated using responses to a 120-item questionnaire. Seed regions were identified for resting state brain networks important for higher-order cognitive processes and for areas that have shown differences in volume and functional activity associated with cognitive complaints in prior studies. Results indicated a positive correlation between the executive control network and cognitive complaint score, weaker negative functional connectivity within the frontal cortex, and stronger positive connectivity within the right middle temporal gyrus in postmenopausal women who report more cognitive complaints. While longitudinal studies are needed to confirm this hypothesis, these data are consistent with previous findings suggesting that high levels of cognitive complaints may reflect changes in brain connectivity and may be a potential marker for the risk of late-life cognitive dysfunction in postmenopausal women with otherwise normal cognitive performance.

Keywords: functional connectivity; post-menopausal women; resting state fMRI; subjective cognitive complaints; subjective cognitive impairment

References

  1. Neurology. 2006 Sep 12;67(5):834-42 - PubMed
  2. Neurology. 1974 Nov;24(11):1019-25 - PubMed
  3. Philos Trans R Soc Lond B Biol Sci. 2012 May 19;367(1594):1338-49 - PubMed
  4. Neuroscience. 2006;138(3):1027-30 - PubMed
  5. J Neuroendocrinol. 2007 Feb;19(2):77-81 - PubMed
  6. Brain Connect. 2015 Oct;5(8):461-75 - PubMed
  7. Biol Psychiatry. 2013 Sep 1;74(5):340-7 - PubMed
  8. Eur Neuropsychopharmacol. 2010 Aug;20(8):519-34 - PubMed
  9. J Alzheimers Dis. 2013;35(4):751-60 - PubMed
  10. Alzheimers Dement. 2014 Jan;10 (1):76-83 - PubMed
  11. Menopause. 2000 Jul-Aug;7(4):257-65 - PubMed
  12. Aging Ment Health. 2008 Mar;12(2):177-82 - PubMed
  13. Maturitas. 2010 May;66(1):56-71 - PubMed
  14. Am J Psychiatry. 2012 Oct;169(10):1092-9 - PubMed
  15. Am J Geriatr Psychiatry. 2010 Aug;18(8):701-10 - PubMed
  16. Arch Neurol. 2012 Feb;69(2):223-9 - PubMed
  17. Br J Psychiatry. 2011 Mar;198(3):199-205 - PubMed
  18. Arch Gen Psychiatry. 2010 Apr;67(4):414-22 - PubMed
  19. Nat Rev Neurosci. 2007 Sep;8(9):700-11 - PubMed
  20. Am J Psychiatry. 1999 Apr;156(4):531-7 - PubMed
  21. Menopause. 2013 Dec;20(12):1231-2 - PubMed
  22. Alzheimers Dement. 2010 Jan;6(1):11-24 - PubMed
  23. Neurosci Res. 2010 Nov;68(3):199-206 - PubMed
  24. Dement Geriatr Cogn Disord. 2003;15(4):218-25 - PubMed
  25. J Neurosci. 2006 Dec 20;26(51):13338-43 - PubMed
  26. Am J Psychiatry. 1993 Apr;150(4):680-2 - PubMed
  27. Lancet Neurol. 2009 Jul;8(7):619-27 - PubMed
  28. Arch Gerontol Geriatr. 2010 Nov-Dec;51(3):e110-4 - PubMed
  29. Neuroimage. 2003 Jul;19(3):1233-9 - PubMed
  30. Int J Geriatr Psychiatry. 2012 Aug;27(8):836-43 - PubMed
  31. J Alzheimers Dis. 2011;23(2):319-26 - PubMed
  32. Psychol Med. 1994 May;24(2):365-74 - PubMed
  33. JAMA. 2002 Nov 6;288(17):2170-2 - PubMed
  34. Menopause. 2009 Jul-Aug;16(4):694-700 - PubMed
  35. Cortex. 2015 Mar;64:271-80 - PubMed
  36. Int J Geriatr Psychiatry. 2000 Nov;15(11):983-91 - PubMed
  37. Psychol Med. 2011 Sep;41(9):1879-88 - PubMed
  38. Hippocampus. 2013 Jan;23 (1):1-6 - PubMed
  39. Int J Geriatr Psychiatry. 2012 Nov;27(11):1180-8 - PubMed
  40. J Neurophysiol. 2008 Dec;100(6):3328-42 - PubMed
  41. Arch Gen Psychiatry. 1961 Jun;4:561-71 - PubMed
  42. J Alzheimers Dis. 2011;27(1):39-47 - PubMed
  43. Psychol Med. 2007 Dec;37(12):1753-62 - PubMed
  44. Psychoneuroendocrinology. 2015 Sep;59:14-24 - PubMed
  45. J Psychiatr Res. 1975 Nov;12(3):189-98 - PubMed
  46. Dement Geriatr Cogn Disord. 2006;22(5-6):471-85 - PubMed
  47. J Womens Health Gend Based Med. 2001 May;10(4):351-62 - PubMed
  48. Psychol Aging. 1990 Dec;5(4):482-90 - PubMed
  49. Alzheimers Dement. 2014 Nov;10(6):844-52 - PubMed
  50. Menopause. 2013 Dec;20(12):1236-42 - PubMed
  51. BMJ. 2003 Feb 1;326(7383):245 - PubMed
  52. Alzheimer Dis Assoc Disord. 1999 Oct-Dec;13(4):216-21 - PubMed
  53. J Psychosom Res. 2009 May;66(5):435-44 - PubMed
  54. J Neurosci. 2011 May 25;31(21):7775-83 - PubMed
  55. Neuropsychologia. 2012 Oct;50(12):2880-6 - PubMed
  56. Neurobiol Aging. 2006 Nov;27(11):1613-7 - PubMed
  57. J Neurosci. 2007 Feb 28;27(9):2349-56 - PubMed
  58. Neurology. 2012 Sep 25;79(13):1332-9 - PubMed
  59. Biol Psychiatry. 1979 Oct;14(5):791-801 - PubMed
  60. Eur Psychiatry. 2011 Oct;26(7):457-62 - PubMed
  61. Neurobiol Aging. 2013 Apr;34(4):1145-7 - PubMed
  62. Brain Connect. 2013;3(4):353-62 - PubMed
  63. Am J Geriatr Psychiatry. 2015 May;23(5):446-55 - PubMed
  64. Proc Natl Acad Sci U S A. 2001 Jan 16;98 (2):676-82 - PubMed
  65. J Int Neuropsychol Soc. 2011 Nov;17(6):1104-12 - PubMed
  66. Curr Psychiatry Rep. 2014 Oct;16(10 ):490 - PubMed
  67. J Neurophysiol. 2011 Sep;106(3):1125-65 - PubMed
  68. Neurology. 2012 Feb 7;78(6):387-95 - PubMed
  69. Neuroscience. 2006;138(3):1021-6 - PubMed
  70. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7209-14 - PubMed
  71. Biol Psychiatry. 2010 Mar 15;67(6):584-7 - PubMed
  72. J Neurosci. 2013 Oct 16;33(42):16657-65 - PubMed
  73. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8 - PubMed
  74. Alzheimers Dement. 2007 Apr;3(2):92-7 - PubMed
  75. Climacteric. 2010 Feb;13(1):84-98 - PubMed
  76. Geriatr Gerontol Int. 2013 Jan;13(1):139-45 - PubMed
  77. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10046-51 - PubMed
  78. Brain Connect. 2012;2(3):125-41 - PubMed
  79. Alzheimers Dement. 2010 Jul;6(4):303-11 - PubMed
  80. Neuropsychology. 2011 Jan;25(1):125-30 - PubMed
  81. Int J Geriatr Psychiatry. 2009 Aug;24(8):865-74 - PubMed
  82. J Psychiatr Res. 1982-1983;17(1):37-49 - PubMed
  83. Menopause. 2012 Jul;19(7):735-41 - PubMed
  84. Age (Dordr). 2012 Apr;34(2):497-506 - PubMed

Publication Types

Grant support