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Kim AY, Jung SY, Choi JY, et al. Retrospective Multicenter Study of Respiratory Syncytial Virus Prophylaxis in Korean Children with Congenital Heart Diseases. Korean Circ J. 2016;46(5):719-726doi: 10.4070/kcj.2016.46.5.719.
Kim, A. Y., Jung, S. Y., Choi, J. Y., Kim, G. B., Kim, Y. H., Shim, W. S., Kang, I. S., & Jung, J. W. (2016). Retrospective Multicenter Study of Respiratory Syncytial Virus Prophylaxis in Korean Children with Congenital Heart Diseases. Korean circulation journal, 46(5), 719-726. https://doi.org/10.4070/kcj.2016.46.5.719
Kim, Ah Young, et al. "Retrospective Multicenter Study of Respiratory Syncytial Virus Prophylaxis in Korean Children with Congenital Heart Diseases." Korean circulation journal vol. 46,5 (2016): 719-726. doi: https://doi.org/10.4070/kcj.2016.46.5.719
Kim AY, Jung SY, Choi JY, Kim GB, Kim YH, Shim WS, Kang IS, Jung JW. Retrospective Multicenter Study of Respiratory Syncytial Virus Prophylaxis in Korean Children with Congenital Heart Diseases. Korean Circ J. 2016 Sep;46(5):719-726. doi: 10.4070/kcj.2016.46.5.719. Epub 2016 Sep 28. PMID: 27721865; PMCID: PMC5054186.
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Korean Circ J. 2016 Sep;46(5):719-726. doi: 10.4070/kcj.2016.46.5.719. Epub 2016 Sep 28.

Retrospective Multicenter Study of Respiratory Syncytial Virus Prophylaxis in Korean Children with Congenital Heart Diseases.

Korean circulation journal

Ah Young Kim, Se Yong Jung, Jae Young Choi, Gi Beom Kim, Young-Hwue Kim, Woo Sup Shim, I-Seok Kang, Jo Won Jung

Affiliations

  1. Yonsei University Severance Cardiovascular, Seoul, Korea.
  2. Seoul National University Children's Hospital, Seoul, Korea.
  3. Ulsan University Asan Medical Center, Seoul, Korea.
  4. Gangwon National University, Chuncheon, Korea.
  5. Sungkyunkwan University Samsung Medical Center, Seoul, Korea.

PMID: 27721865 PMCID: PMC5054186 DOI: 10.4070/kcj.2016.46.5.719

Abstract

BACKGROUND AND OBJECTIVES: We conducted a review of current data on respiratory syncytial virus (RSV) prophylaxis with palivizumab, in Korean children with congenital heart diseases (CHD). In 2009, the Korean guideline for RSV prophylaxis had established up to five shots monthly per RSV season, only for children <1 year of age with hemodynamic significance CHD (HS-CHD).

SUBJECTS AND METHODS: During the RSV seasons in 2009-2015, we performed a retrospective review of data for 466 infants with CHD, examined at six centers in Korea.

RESULTS: Infants received an average of 3.7±1.9 (range, 1-10) injections during the RSV season. Fifty-seven HS-CHD patients (12.2%) were hospitalized with breakthrough RSV bronchiolitis, with a recurrence in three patients, one year after the initial check-up. Among patients with simple CHD, only five (1.1%) patients received one additional dose postoperatively, as per the limitations set by the Korean guideline. Among the 30 deaths (6.4%), five (1.1%) were attributed to RSV infection; three to simple CHD, one to Tetralogy of Fallot, and one to hypertrophic cardiomyopathy (HCM). Of the three HCM patients that exceeded guidelines for RSV prophylaxis, two (66.6%) were hospitalized, and one died of RSV infection (33.3%).

CONCLUSION: In accordance to the Korean guideline, minimal injections of palivizumab were administered to patients having HS-CHD

Keywords: Congenital heart disease; Palivizumab; Pediatrics; Prophylaxis; Respiratory syncytial virus

Conflict of interest statement

The authors have no financial conflicts of interest.

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