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Sebastiani F, Cortesi L, Sant M, et al. Increased Incidence of Breast Cancer in Postmenopausal Women with High Body Mass Index at the Modena Screening Program. J Breast Cancer. 2016;19(3):283-291doi: 10.4048/jbc.2016.19.3.283.
Sebastiani, F., Cortesi, L., Sant, M., Lucarini, V., Cirilli, C., De Matteis, E., Marchi, I., Negri, R., Gallo, E., & Federico, M. (2016). Increased Incidence of Breast Cancer in Postmenopausal Women with High Body Mass Index at the Modena Screening Program. Journal of breast cancer, 19(3), 283-291. https://doi.org/10.4048/jbc.2016.19.3.283
Sebastiani, Federica, et al. "Increased Incidence of Breast Cancer in Postmenopausal Women with High Body Mass Index at the Modena Screening Program." Journal of breast cancer vol. 19,3 (2016): 283-291. doi: https://doi.org/10.4048/jbc.2016.19.3.283
Sebastiani F, Cortesi L, Sant M, Lucarini V, Cirilli C, De Matteis E, Marchi I, Negri R, Gallo E, Federico M. Increased Incidence of Breast Cancer in Postmenopausal Women with High Body Mass Index at the Modena Screening Program. J Breast Cancer. 2016 Sep;19(3):283-291. doi: 10.4048/jbc.2016.19.3.283. Epub 2016 Sep 23. PMID: 27721878; PMCID: PMC5053313.
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J Breast Cancer. 2016 Sep;19(3):283-291. doi: 10.4048/jbc.2016.19.3.283. Epub 2016 Sep 23.

Increased Incidence of Breast Cancer in Postmenopausal Women with High Body Mass Index at the Modena Screening Program.

Journal of breast cancer

Federica Sebastiani, Laura Cortesi, Milena Sant, Valeria Lucarini, Claudia Cirilli, Elisabetta De Matteis, Isabella Marchi, Rossella Negri, Ennio Gallo, Massimo Federico

Affiliations

  1. Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Modena, Italy.
  2. Department of Oncology, Hematology, and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy.
  3. Department of Preventive and Predictive Medicine, National Tumor Institute, Milan, Italy.
  4. Department of Radiology, University of Modena and Reggio Emilia, Modena, Italy.

PMID: 27721878 PMCID: PMC5053313 DOI: 10.4048/jbc.2016.19.3.283

Abstract

PURPOSE: We conducted a study to evaluate the relationship between body mass index (BMI) and the risk of breast cancer (BC) and outcome in a population of 14,684 women aged 55 to 69 years eligible to participate in the Mammography Screening Program (MSP) in the Province of Modena, Italy.

METHODS: The study population was drawn from women who underwent mammography screening between 2004 and 2006 in the Province of Modena. Women were subdivided into obese, overweight, and normal-weight categories according to BMI and followed until July 31, 2010, to evaluate the BC incidence. The clinicopathological characteristics of BC were also evaluated in different groups of patients classified according to BMI. After BC diagnosis, patients were followed for a median period of 65 (range, 2-104) months. Second events (recurrences and second tumors) were recorded, and the 5-year event-free survival (EFS) was calculated.

RESULTS: After a period of 73 months, 366 cases of BC were diagnosed. Compared with normal-weight women, obese women had a significantly higher incidence of BC (relative risk [RR], 1.32;

CONCLUSION: We observed a significantly higher risk of BC in obese women among those eligible to participate in the MSP in the Province of Modena. Finally, obese women had more second events and poorer EFS compared to nono bese women.

Keywords: Body mass index; Breast neoplasms; Mammography; Mass screening; Outcome assessment

Conflict of interest statement

The authors declare that they have no competing interests.

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