Display options
Cite
Hussain A, Bennett RT, Chaudhry MA, et al. Characterization of optimal resting tension in human pulmonary arteries. World J Cardiol. 2016;8(9):553-558doi: 10.4330/wjc.v8.i9.553.
Hussain, A., Bennett, R. T., Chaudhry, M. A., Qadri, S. S., Cowen, M., Morice, A. H., & Loubani, M. (2016). Characterization of optimal resting tension in human pulmonary arteries. World journal of cardiology, 8(9), 553-558. https://doi.org/10.4330/wjc.v8.i9.553
Hussain, Azar, et al. "Characterization of optimal resting tension in human pulmonary arteries." World journal of cardiology vol. 8,9 (2016): 553-558. doi: https://doi.org/10.4330/wjc.v8.i9.553
Hussain A, Bennett RT, Chaudhry MA, Qadri SS, Cowen M, Morice AH, Loubani M. Characterization of optimal resting tension in human pulmonary arteries. World J Cardiol. 2016 Sep 26;8(9):553-558. doi: 10.4330/wjc.v8.i9.553. PMID: 27721938; PMCID: PMC5039357.
Copy Download .nbib Format: NLM
Share it on

World J Cardiol. 2016 Sep 26;8(9):553-558. doi: 10.4330/wjc.v8.i9.553.

Characterization of optimal resting tension in human pulmonary arteries.

World journal of cardiology

Azar Hussain, Robert T Bennett, Mubarak A Chaudhry, Syed S Qadri, Mike Cowen, Alyn H Morice, Mahmoud Loubani

Affiliations

  1. Azar Hussain, Robert T Bennett, Mubarak A Chaudhry, Syed S Qadri, Mike Cowen, Mahmoud Loubani, Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham HU16 5JQ, United Kingdom.

PMID: 27721938 PMCID: PMC5039357 DOI: 10.4330/wjc.v8.i9.553

Abstract

AIM: To determine the optimum resting tension (ORT) for in vitro human pulmonary artery (PA) ring preparations.

METHODS: Pulmonary arteries were dissected from disease free sections of the resected lung in the operating theatre and tissue samples were directly sent to the laboratory in Krebs-Henseleit solution (Krebs). The pulmonary arteries were then cut into 2 mm long rings. PA rings were mounted in 25 mL organ baths or 8 mL myograph chambers containing Krebs compound (37 °C, bubbled with 21% O

RESULTS: Twenty PA rings of internal diameter between 2-4 mm were prepared from 4 patients. In human PA rings incrementing the tension during rest stance by 0.6 gf, up to 1.6 gf significantly augmented the 40 mmol/L KCl stimulated tension. Further enhancement of active tension by 0.4 gf, up to 2.0 gf mitigate the 40 mmol/L KCl stimulated reaction. Both Myograph and the organ bath demonstrated identical conclusions, supporting that the radial optimal resting tension for human PA ring was 1.61 g.

CONCLUSION: The radial optimal resting tension in our experiment is 1.61 gf (15.78 mN) for human PA rings.

Keywords: Human; Optimal resting tension; Pulmonary artery; Pulmonary artery rings; Pulmonary hypertension

Conflict of interest statement

Conflict-of-interest statement: There are no conflicts of interest to report.

References

  1. J Clin Invest. 2012 Nov;122(11):4218-30 - PubMed
  2. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L725-36 - PubMed
  3. Circulation. 2001 Apr 24;103(16):2078-83 - PubMed
  4. Circulation. 1966 Jan;33(1):146-58 - PubMed
  5. Can J Physiol Pharmacol. 1998 Jan;76(1):72-6 - PubMed
  6. Circ Res. 1983 May;52(5):527-33 - PubMed
  7. Curr Opin Pharmacol. 2009 Jun;9(3):287-96 - PubMed
  8. Anesthesiology. 2015 Apr;122(4):932-46 - PubMed
  9. High Alt Med Biol. 2013 Jun;14 (2):101-10 - PubMed
  10. Clin Exp Pharmacol Physiol. 2007 Jul;34(7):665-71 - PubMed
  11. Biomed Res Int. 2013;2013:623684 - PubMed
  12. Br J Anaesth. 2004 Jul;93(1):105-13 - PubMed
  13. J Pharmacol Toxicol Methods. 2000 Sep-Oct;44(2):333-40 - PubMed
  14. Nat Rev Cardiol. 2010 Nov;7(11):648-59 - PubMed

Publication Types