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Khosravi M, Saadat I, Karimi MH, et al. Association of GSTO2 (N142D) Genetic Polymorphism and Acute Rejection of Liver. Int J Organ Transplant Med. 2016;7(3):183-187
Khosravi, M., Saadat, I., Karimi, M. H., & Malek Hosseini, S. A. (2016). Association of GSTO2 (N142D) Genetic Polymorphism and Acute Rejection of Liver. International journal of organ transplantation medicine, 7(3), 183-187.
Khosravi, M, et al. "Association of GSTO2 (N142D) Genetic Polymorphism and Acute Rejection of Liver." International journal of organ transplantation medicine vol. 7,3 (2016): 183-187.
Khosravi M, Saadat I, Karimi MH, Malek Hosseini SA. Association of GSTO2 (N142D) Genetic Polymorphism and Acute Rejection of Liver. Int J Organ Transplant Med. 2016;7(3):183-187. Epub 2016 Aug 01. PMID: 27721965; PMCID: PMC5054142.
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Int J Organ Transplant Med. 2016;7(3):183-187. Epub 2016 Aug 01.

Association of GSTO2 (N142D) Genetic Polymorphism and Acute Rejection of Liver.

International journal of organ transplantation medicine

M Khosravi, I Saadat, M H Karimi, S A Malek Hosseini

Affiliations

  1. Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
  2. Transplant Research Center, Shiraz University of Medical Sciences, Namazi Hospital, Shiraz, Iran.

PMID: 27721965 PMCID: PMC5054142

Abstract

BACKGROUND: Acute rejection is the main problem in liver transplantation that occurs in the first days or months of transplantation. It includes histological and cellular rejection. Acute histological rejection is confirmed by biopsy. Glutathione S-transferase family is the most important genes in phase II detoxification working in xenobiotic and drug metabolism

OBJECTIVE: To determine if

METHODS: The present study included 120 patients with histological-proven acute liver rejection and 182 patients without acute rejection. Both groups were matched for sex and age. To determine variants of

RESULTS: There was a significant association between the

CONCLUSION: Recipients with either NN or ND genotype for

Keywords: Glutathione S-Transferase; Graft rejection; Metabolic Detoxication; Phase II; Polymorphism; genetic; transplantation

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