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Arias JF, Colomer-Lluch M, von Bredow B, et al. Tetherin Antagonism by HIV-1 Group M Nef Proteins. J Virol. 2016;90(23):10701-10714doi: 10.1128/JVI.01465-16.
Arias, J. F., Colomer-Lluch, M., von Bredow, B., Greene, J. M., MacDonald, J., O'Connor, D. H., Serra-Moreno, R., & Evans, D. T. (2016). Tetherin Antagonism by HIV-1 Group M Nef Proteins. Journal of virology, 90(23), 10701-10714. https://doi.org/10.1128/JVI.01465-16
Arias, Juan F, et al. "Tetherin Antagonism by HIV-1 Group M Nef Proteins." Journal of virology vol. 90,23 (2016): 10701-10714. doi: https://doi.org/10.1128/JVI.01465-16
Arias JF, Colomer-Lluch M, von Bredow B, Greene JM, MacDonald J, O'Connor DH, Serra-Moreno R, Evans DT. Tetherin Antagonism by HIV-1 Group M Nef Proteins. J Virol. 2016 Nov 14;90(23):10701-10714. doi: 10.1128/JVI.01465-16. Print 2016 Dec 01. PMID: 27654287; PMCID: PMC5110183.
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J Virol. 2016 Nov 14;90(23):10701-10714. doi: 10.1128/JVI.01465-16. Print 2016 Dec 01.

Tetherin Antagonism by HIV-1 Group M Nef Proteins.

Journal of virology

Juan F Arias, Marta Colomer-Lluch, Benjamin von Bredow, Justin M Greene, Julie MacDonald, David H O'Connor, Ruth Serra-Moreno, David T Evans

Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  2. Department of Biological Sciences, College of Arts and Sciences, Texas Tech University, Lubbock, Texas, USA.
  3. Oregon Health & Science University, Portland, Oregon, USA.
  4. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  5. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA [email protected].

PMID: 27654287 PMCID: PMC5110183 DOI: 10.1128/JVI.01465-16

Abstract

Although Nef is the viral gene product used by most simian immunodeficiency viruses to overcome restriction by tetherin, this activity was acquired by the Vpu protein of HIV-1 group M due to the absence of sequences in human tetherin that confer susceptibility to Nef. Thus, it is widely accepted that HIV-1 group M uses Vpu instead of Nef to counteract tetherin. Challenging this paradigm, we identified Nef alleles of HIV-1 group M isolates with significant activity against human tetherin. These Nef proteins promoted virus release and tetherin downmodulation from the cell surface and, in the context of

Copyright © 2016, American Society for Microbiology. All Rights Reserved.

References

  1. J Virol. 2009 Sep;83(17):8771-80 - PubMed
  2. Cell Host Microbe. 2009 Nov 19;6(5):409-21 - PubMed
  3. J Virol. 2014 May;88(10):5845-58 - PubMed
  4. Nature. 2008 Jan 24;451(7177):425-30 - PubMed
  5. J Virol. 2003 Oct;77(19):10548-56 - PubMed
  6. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1343-52 - PubMed
  7. Cell. 2009 Oct 30;139(3):499-511 - PubMed
  8. Cell Host Microbe. 2011 Jan 20;9(1):46-57 - PubMed
  9. Bioinformatics. 2012 Jun 15;28(12):1647-9 - PubMed
  10. J Virol. 1986 Aug;59(2):284-91 - PubMed
  11. Elife. 2014 Apr 29;3:e02362 - PubMed
  12. Science. 2006 Jul 28;313(5786):523-6 - PubMed
  13. Clin Microbiol Rev. 2013 Jul;26(3):448-61 - PubMed
  14. J Biol Chem. 2012 Jun 22;287(26):22015-29 - PubMed
  15. J Virol. 2015 Oct;89(20):10648-55 - PubMed
  16. Cell Host Microbe. 2014 Sep 10;16(3):291-303 - PubMed
  17. PLoS Pathog. 2009 May;5(5):e1000429 - PubMed
  18. PLoS Pathog. 2014 Jan;10(1):e1003895 - PubMed
  19. J Virol. 2013 Feb;87(4):2046-57 - PubMed
  20. Lancet. 2011 Nov 26;378(9806):1894 - PubMed
  21. J Biol Chem. 2012 Jan 2;287(1):58-67 - PubMed
  22. PLoS Pathog. 2012;8(8):e1002890 - PubMed
  23. J Virol. 1993 Aug;67(8):5056-61 - PubMed
  24. J Biol Chem. 2015 Apr 24;290(17):10919-33 - PubMed
  25. J Virol. 2009 Nov;83(22):11966-78 - PubMed
  26. Traffic. 2003 Oct;4(10):694-709 - PubMed
  27. J Virol. 2010 Dec;84(24):12958-70 - PubMed
  28. Nat Med. 2010 Apr;16(4):446-51 - PubMed
  29. J Virol. 2009 Feb;83(4):1837-44 - PubMed
  30. Antiviral Res. 2011 Sep;91(3):321-9 - PubMed
  31. PLoS Pathog. 2011 May;7(5):e1002039 - PubMed
  32. J Virol. 2009 Mar;83(5):2382-5 - PubMed
  33. J Virol. 2009 Oct;83(19):9672-81 - PubMed
  34. Cell Host Microbe. 2012 Nov 15;12 (5):633-44 - PubMed
  35. Retrovirology. 2014 Feb 06;11:15 - PubMed
  36. J Virol. 2010 Apr;84(8):4089-94 - PubMed
  37. J Virol. 2011 Oct;85(19):9834-46 - PubMed
  38. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17 ):6425-30 - PubMed
  39. J Virol. 2005 May;79(9):5489-98 - PubMed
  40. J Virol. 2014 Jun;88(11):6031-46 - PubMed
  41. AIDS Res Hum Retroviruses. 1995 Jul;11(7):783-7 - PubMed
  42. J Virol. 2014 May;88(9):5062-78 - PubMed
  43. PLoS Pathog. 2013;9(4):e1003299 - PubMed
  44. J Virol. 2014 Mar;88(5):2633-44 - PubMed
  45. PLoS Pathog. 2013;9(7):e1003487 - PubMed
  46. Cell Host Microbe. 2008 Apr 17;3(4):245-52 - PubMed
  47. PLoS Pathog. 2010 Mar 05;6(3):e1000701 - PubMed
  48. J Virol. 2016 Jul 11;90(15):6709-23 - PubMed
  49. PLoS Pathog. 2010 Feb 05;6(2):e1000749 - PubMed
  50. PLoS Pathog. 2012 Sep;8(9):e1002931 - PubMed
  51. Cell Host Microbe. 2009 Jul 23;6(1):54-67 - PubMed
  52. J Virol. 2012 Nov;86(22):12039-52 - PubMed
  53. J Cell Sci. 2007 Nov 1;120(Pt 21):3850-8 - PubMed
  54. Cell Host Microbe. 2014 Nov 12;16(5):639-50 - PubMed
  55. J Virol. 1999 Nov;73(11):8966-74 - PubMed
  56. Sci Rep. 2015 Dec 16;5:18499 - PubMed
  57. J Virol. 2010 Dec;84(24):12646-57 - PubMed

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