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Frindik JP, Arnold WC, Ellis E. Chronic Low Dose Growth Hormone Treatment Stimulates Both Hypertrophy and Hyperplasia of Remnant Kidneys in Uraemic Rats. Clin Drug Investig. 1995;10(3):183-7doi: 10.2165/00044011-199510030-00008.
Frindik, J. P., Arnold, W. C., & Ellis, E. (1995). Chronic Low Dose Growth Hormone Treatment Stimulates Both Hypertrophy and Hyperplasia of Remnant Kidneys in Uraemic Rats. Clinical drug investigation, 10(3), 183-7. https://doi.org/10.2165/00044011-199510030-00008
Frindik, J P, et al. "Chronic Low Dose Growth Hormone Treatment Stimulates Both Hypertrophy and Hyperplasia of Remnant Kidneys in Uraemic Rats." Clinical drug investigation vol. 10,3 (1995): 183-7. doi: https://doi.org/10.2165/00044011-199510030-00008
Frindik JP, Arnold WC, Ellis E. Chronic Low Dose Growth Hormone Treatment Stimulates Both Hypertrophy and Hyperplasia of Remnant Kidneys in Uraemic Rats. Clin Drug Investig. 1995 Sep;10(3):183-7. doi: 10.2165/00044011-199510030-00008. PMID: 27519203.
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Clin Drug Investig. 1995 Sep;10(3):183-7. doi: 10.2165/00044011-199510030-00008.

Chronic Low Dose Growth Hormone Treatment Stimulates Both Hypertrophy and Hyperplasia of Remnant Kidneys in Uraemic Rats.

Clinical drug investigation

J P Frindik, W C Arnold, E Ellis

Affiliations

  1. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  2. Department of Pediatric Nephrology, Cook-Fort Worth Children's Medical Center, Fort Worth, Texas, USA.

PMID: 27519203 DOI: 10.2165/00044011-199510030-00008

Abstract

CONCLUSION: In conclusion, low doses of exogenous rhGH, when administered in a manner similar to clinical practice, are associated with glomerular enlargement and stimulation of hypertrophy and hyperplasia of remnant kidneys from uraemic rats. Increased GV was also seen after short term, high dose rhGH therapy in our previous study.([4]) The time interval required before increased GV develops with low dose rhGH therapy and whether or not further rhGH exposure subsequently leads to worsening glomerular hypertrophy, glomerulosclerosis([7]) and renal failure cannot be determined from the current study. Although we observed no significant changes in renal function with rhGH therapy, we recommend that children with CRI be carefully monitored to ensure that long term rhGH treatment has no such deleterious effects.

References

  1. Kidney Int. 1982 May;21(5):689-95 - PubMed
  2. Am J Dis Child. 1987 May;141(5):502-5 - PubMed
  3. Acta Endocrinol (Copenh). 1984 Jun;106(2):184-7 - PubMed
  4. Pediatr Nephrol. 1991 Jul;5(4):529-32 - PubMed
  5. Pediatr Res. 1989 Sep;26(3):204-7 - PubMed
  6. Pediatr Nephrol. 1990 Nov;4(6):654-62 - PubMed
  7. Kidney Int Suppl. 1983 Nov;15:S53-62 - PubMed
  8. Pediatr Nephrol. 1992 May;6(3):262-6 - PubMed
  9. J Pediatr. 1994 Mar;124(3):374-82 - PubMed
  10. Kidney Int. 1983 Aug;24(2):205-9 - PubMed
  11. Kidney Int. 1993 Dec;44(6):1251-8 - PubMed
  12. Am J Pathol. 1988 Jun;131(3):398-403 - PubMed
  13. Diabetes Care. 1991 May;14(5):413-4 - PubMed
  14. Endocrinology. 1988 Jul;123(1):44-9 - PubMed
  15. Pediatr Nephrol. 1988 Oct;2(4):425-30 - PubMed
  16. Anal Biochem. 1980 Mar 1;102(2):344-52 - PubMed
  17. Pediatr Res. 1992 Apr;31(4 Pt 1):406-10 - PubMed
  18. Regul Pept. 1984 Dec;10(1):37-45 - PubMed
  19. J Am Soc Nephrol. 1992 Mar;2(9):1417-22 - PubMed

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