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Gentry C, Blower P, Spangler R. Effect of 6-Methoxy-2-Naphthylacetic Acid (6MNA), the Active Metabolite of Nabumetone, on the Glycosaminoglycan Synthesis of Canine Articular Cartilage In Vitro : Comparison with Other Nonsteroidal Anti-Inflammatory Drugs. Clin Drug Investig. 1995;10(6):355-64doi: 10.2165/00044011-199510060-00006.
Gentry, C., Blower, P., & Spangler, R. (1995). Effect of 6-Methoxy-2-Naphthylacetic Acid (6MNA), the Active Metabolite of Nabumetone, on the Glycosaminoglycan Synthesis of Canine Articular Cartilage In Vitro : Comparison with Other Nonsteroidal Anti-Inflammatory Drugs. Clinical drug investigation, 10(6), 355-64. https://doi.org/10.2165/00044011-199510060-00006
Gentry, C, et al. "Effect of 6-Methoxy-2-Naphthylacetic Acid (6MNA), the Active Metabolite of Nabumetone, on the Glycosaminoglycan Synthesis of Canine Articular Cartilage In Vitro : Comparison with Other Nonsteroidal Anti-Inflammatory Drugs." Clinical drug investigation vol. 10,6 (1995): 355-64. doi: https://doi.org/10.2165/00044011-199510060-00006
Gentry C, Blower P, Spangler R. Effect of 6-Methoxy-2-Naphthylacetic Acid (6MNA), the Active Metabolite of Nabumetone, on the Glycosaminoglycan Synthesis of Canine Articular Cartilage In Vitro : Comparison with Other Nonsteroidal Anti-Inflammatory Drugs. Clin Drug Investig. 1995 Dec;10(6):355-64. doi: 10.2165/00044011-199510060-00006. PMID: 27519337.
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Clin Drug Investig. 1995 Dec;10(6):355-64. doi: 10.2165/00044011-199510060-00006.

Effect of 6-Methoxy-2-Naphthylacetic Acid (6MNA), the Active Metabolite of Nabumetone, on the Glycosaminoglycan Synthesis of Canine Articular Cartilage In Vitro : Comparison with Other Nonsteroidal Anti-Inflammatory Drugs.

Clinical drug investigation

C Gentry, P Blower, R Spangler

Affiliations

  1. Research and Development Technologies, SmithKline Beecham Pharmaceuticals, Harlow, Essex, England.
  2. ITR Medical and Scientific Affairs, SmithKline Beecham Pharmaceuticals, Philadelphia, Pennsylvania, USA.

PMID: 27519337 DOI: 10.2165/00044011-199510060-00006

Abstract

6-methoxy-2-naphthylacetic acid (6MNA), the active metabolite of nabumetone, a novel nonacidic NSAID, has been studied in an in vitro culture system to determine its effects on glycosaminoglycan synthesis of normal and osteoarthritic canine articular cartilage. The effects were contrasted with those of several other NSAIDs. Dexamethasone potently inhibited synthesis and was used as a positive control in these studies. To reduce the influence of protein binding with these drugs, experiments were performed both in the presence and in the absence of serum in the culture medium. At and above concentrations achieved in the plasma of nabumetone-treated patients, 6MNA did not inhibit glycosaminoglycan synthesis of normal or osteoarthritic cartilage. In contrast, some other NSAIDs had the propensity to significantly suppress chondrocyte synthetic activity.

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