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Umemoto K, Kojima Y, Nagata N, et al. Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports. J Med Case Rep. 2016;10(1):259doi: 10.1186/s13256-016-0947-y.
Umemoto, K., Kojima, Y., Nagata, N., Yokoi, C., Sakurai, T., Kobayakawa, M., Iizuka, T., Igari, T., Yanase, M., & Akiyama, J. (2016). Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports. Journal of medical case reports, 10(1), 259. https://doi.org/10.1186/s13256-016-0947-y
Umemoto, Kumiko, et al. "Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports." Journal of medical case reports vol. 10,1 (2016): 259. doi: https://doi.org/10.1186/s13256-016-0947-y
Umemoto K, Kojima Y, Nagata N, Yokoi C, Sakurai T, Kobayakawa M, Iizuka T, Igari T, Yanase M, Akiyama J. Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports. J Med Case Rep. 2016 Sep 21;10(1):259. doi: 10.1186/s13256-016-0947-y. PMID: 27655584; PMCID: PMC5031298.
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J Med Case Rep. 2016 Sep 21;10(1):259. doi: 10.1186/s13256-016-0947-y.

Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports.

Journal of medical case reports

Kumiko Umemoto, Yasushi Kojima, Naoyoshi Nagata, Chizu Yokoi, Toshiyuki Sakurai, Masao Kobayakawa, Toshihiko Iizuka, Toru Igari, Mikio Yanase, Junichi Akiyama

Affiliations

  1. Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan. [email protected].
  2. Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.
  3. Departments of Clinical Pathology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, 162-8655, Tokyo, Japan.

PMID: 27655584 PMCID: PMC5031298 DOI: 10.1186/s13256-016-0947-y

Abstract

BACKGROUND: It is well known that cytomegalovirus esophagitis occurs in immunosuppressed patients. However, few reports have described cytomegalovirus esophagitis occurring during chemoradiotherapy for esophageal cancer.

CASE PRESENTATION: We report two cases of patients with cytomegalovirus esophagitis that developed during chemoradiotherapy for esophageal cancer. Cytomegalovirus esophagitis was diagnosed based on the presence of intranuclear inclusions in tumor biopsy specimens. The two Japanese patients presented with anorexia and fever, which improved with anti-cytomegalovirus treatment, and intranuclear inclusions were no longer seen in the specimens.

CONCLUSIONS: The possibility of cytomegalovirus esophagitis must be kept in mind for patients with esophageal cancer presenting with prolonged fever or digestive symptoms while receiving chemoradiotherapy.

Keywords: Case report; Cytomegalovirus; Esophageal cancer; Esophagitis

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