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Wang X, Li D, Wu G, et al. Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells. Biol Reprod. 2016;95(5):102doi: 10.1095/biolreprod.116.142281.
Wang, X., Li, D., Wu, G., & Bazer, F. W. (2016). Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells. Biology of reproduction, 95(5), 102. https://doi.org/10.1095/biolreprod.116.142281
Wang, Xiaoqiu, et al. "Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells." Biology of reproduction vol. 95,5 (2016): 102. doi: https://doi.org/10.1095/biolreprod.116.142281
Wang X, Li D, Wu G, Bazer FW. Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells. Biol Reprod. 2016 Nov 01;95(5):102. doi: 10.1095/biolreprod.116.142281. Epub 2016 Sep 21. PMID: 27655785.
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Biol Reprod. 2016 Nov 01;95(5):102. doi: 10.1095/biolreprod.116.142281. Epub 2016 Sep 21.

Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells.

Biology of reproduction

Xiaoqiu Wang, Defa Li, Guoyao Wu, Fuller W Bazer

PMID: 27655785 DOI: 10.1095/biolreprod.116.142281

Abstract

During pregnancy, the placentae of ungulate mammals (e.g., cows, sheep, and pigs) convert glucose into fructose which is the most abundant hexose sugar in fetal fluids and blood. However, the role of fructose, the most enigmatic component of carbohydrate metabolism in fetal-placental tissues, is largely ignored since it is not metabolized via the glycolytic pathway or the Krebs cycle as an energy source. Here we provided evidence for biological functions of fructose that affect proliferative behavior of the conceptus trophectoderm/chorion via activation of the Akt-TSC2-MTOR signaling cascade. The phosphorylation for activation of this cascade is mediated by O-GlcNAcylation from UDP-N-acetylglucosamine (UDP-GlcNAc), a primary product of the hexosamine biosynthesis pathway. These results reveal novel functional roles of fructose in promoting embryonic/fetal growth and development during pregnancy, and also provide new insight into understanding the relationship between excessive fructose intake and metabolic disorders.

Copyright 2016 by The Society for the Study of Reproduction.

Keywords: Fructose; Implantation; Pregnancy; Trophectoderm; mTOR

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