J Clin Diagn Res. 2016 Aug;10(8):BC09-13. doi: 10.7860/JCDR/2016/20715.8347. Epub 2016 Aug 01.
Plasma Myeloperoxidase and Total Sialic Acid as Prognostic Indicators in Acute Coronary Syndrome.
Journal of clinical and diagnostic research : JCDR
Sumitra Govindarajan, Vm Mithun Raghavan, Anand C Vasudeva Rao
Affiliations
Affiliations
- Assistant Professor, Department of Biochemistry, PSG Institute of Medical Sciences and Research , Coimbatore, Tamil Nadu, India .
- Biochemist Incharge, IQRAA International Hospital and Research centre , Calicut, Kerala, India .
- Medical Biochemist/ Quality Manager, Elbit Diagnostics , Bangalore, Karnataka, India .
PMID: 27656431
PMCID: PMC5028599 DOI: 10.7860/JCDR/2016/20715.8347
Abstract
INTRODUCTION: Acute Coronary Syndrome (ACS) is the leading cause of death worldwide. Oxidative stress and inflammation play important role in the destabilization of plaques leading to ACS. Markers which reflect this pathophysiologic mechanism may have prognostic value. Myeloperoxidase (MPO) and Sialic acid are markers of inflammation and oxidative stress. Both these markers are increased in patients with ACS. Their prognostic value in ACS is not well established.
AIM: To analyse the prognostic value of plasma myeloperoxidase and total sialic acid levels in patients with suspected acute coronary syndrome.
MATERIALS AND METHODS: A prospective study was conducted on 93 consecutively admitted patients with chest pain from July 2011 to September 2011. Plasma MPO and total sialic acid levels on admission were estimated spectrophotometrically. These were compared with extent of disease, development of complications during the hospital stay, left ventricular ejection fraction and mean duration of stay in hospital.
RESULTS: Plasma MPO and total sialic acid levels were significantly higher in patients with myocardial infarction than those with unstable and stable angina (p<0.001 and p<0.007 respectively). The levels of plasma MPO and sialic acid levels were significantly higher in patients who developed complications like heart failure, arrhythmias, renal failure during their stay in hospital (p<0.011 and p<0.006 respectively). Ejection fraction was significantly low in patients with high MPO levels (p<0.011).
CONCLUSION: In patients with ACS, plasma MPO and total sialic acid levels on admission could predict the development of complications during their hospital stay. MPO levels correlated with ejection fraction in patients with ACS.
Keywords: Left ventricular ejection fraction; Major adverse cardiac event; Myocardial infarction
References
- Circulation. 1999 Feb 23;99(7):855-60 - PubMed
- Tex Heart Inst J. 2012;39(4):500-6 - PubMed
- Science. 2002 Jun 28;296(5577):2391-4 - PubMed
- Blood. 1982 Sep;60(3):618-22 - PubMed
- Int J Cardiol. 2013 Sep 30;168(2):934-45 - PubMed
- Ann Epidemiol. 2004 Oct;14(9):627-32 - PubMed
- Indian J Clin Biochem. 2006 Mar;21(1):54-61 - PubMed
- J Biol Chem. 2001 Nov 2;276(44):41279-87 - PubMed
- Clin Chem. 2009 Aug;55(8):1462-70 - PubMed
- BMJ. 1991 Jan 19;302(6769):143-6 - PubMed
- Int J Epidemiol. 1996 Oct;25(5):953-8 - PubMed
- Circ Res. 2014 Jun 6;114(12):1867-79 - PubMed
- J Am Coll Cardiol. 2007 May 22;49(20):1993-2000 - PubMed
- Circ J. 2002 Nov;66(11):1019-23 - PubMed
- Clin Chem Lab Med. 2000 Dec;38(12):1249-55 - PubMed
- Arterioscler Thromb Vasc Biol. 2000 Jul;20(7):1716-23 - PubMed
- Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1309-14 - PubMed
- Acta Cardiol. 2007 Aug;62(4):373-80 - PubMed
- Circ J. 2009 Apr;73(4):726-31 - PubMed
- J Lab Clin Med. 2002 Aug;140(2):110-8 - PubMed
- Circulation. 2003 Sep 23;108(12):1440-5 - PubMed
- N Engl J Med. 2003 Oct 23;349(17):1595-604 - PubMed
- Circulation. 2002 Sep 24;106(13):1588-91 - PubMed
- Am J Pathol. 2001 Mar;158(3):879-91 - PubMed
- Biochem J. 1961 Nov;81:384-92 - PubMed
- Heart. 2004 Jul;90(7):729-31 - PubMed
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