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Katukuri GR, Maddala RN, Ramamoorthi K, et al. Cefoperazone Induced Gastrointestinal Bleeding. J Clin Diagn Res. 2016;10(8):OD10-1doi: 10.7860/JCDR/2016/19694.8316.
Katukuri, G. R., Maddala, R. N., Ramamoorthi, K., & Hande, M. (2016). Cefoperazone Induced Gastrointestinal Bleeding. Journal of clinical and diagnostic research : JCDR, 10(8), OD10-1. https://doi.org/10.7860/JCDR/2016/19694.8316
Katukuri, Goutham Reddy, et al. "Cefoperazone Induced Gastrointestinal Bleeding." Journal of clinical and diagnostic research : JCDR vol. 10,8 (2016): OD10-1. doi: https://doi.org/10.7860/JCDR/2016/19694.8316
Katukuri GR, Maddala RN, Ramamoorthi K, Hande M. Cefoperazone Induced Gastrointestinal Bleeding. J Clin Diagn Res. 2016 Aug;10(8):OD10-1. doi: 10.7860/JCDR/2016/19694.8316. Epub 2016 Aug 01. PMID: 27656491; PMCID: PMC5028500.
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J Clin Diagn Res. 2016 Aug;10(8):OD10-1. doi: 10.7860/JCDR/2016/19694.8316. Epub 2016 Aug 01.

Cefoperazone Induced Gastrointestinal Bleeding.

Journal of clinical and diagnostic research : JCDR

Goutham Reddy Katukuri, Raja Naga Mahesh Maddala, Kusugodlu Ramamoorthi, Manjunatha Hande

Affiliations

  1. Junior Resident, Department of General Medicine, Kasturba Medical College, Kasturba Hospital , Manipal, Udupi, Karnataka, India .
  2. Assistant Professor, Department of General Medicine, Kasturba Medical College, Kasturba Hospital , Manipal, Udupi, Karnataka, India .
  3. Professor and HOD, Department of General Medicine, Kasturba Medical College, Kasturba Hospital , Manipal, Udupi, Karnataka, India .

PMID: 27656491 PMCID: PMC5028500 DOI: 10.7860/JCDR/2016/19694.8316

Abstract

Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient's coagulation function disorder and her use of the suspect drug.

Keywords: Cefoperazone; Coagulopathy; Vitamin K

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