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Garg P, Chaman C. Apical Periodontitis - Is It Accountable for Cardiovascular Diseases?. J Clin Diagn Res. 2016;10(8):ZE08-12doi: 10.7860/JCDR/2016/19863.8253.
Garg, P., & Chaman, C. (2016). Apical Periodontitis - Is It Accountable for Cardiovascular Diseases?. Journal of clinical and diagnostic research : JCDR, 10(8), ZE08-12. https://doi.org/10.7860/JCDR/2016/19863.8253
Garg, Paridhi, and Chaman, Chandrakar. "Apical Periodontitis - Is It Accountable for Cardiovascular Diseases?." Journal of clinical and diagnostic research : JCDR vol. 10,8 (2016): ZE08-12. doi: https://doi.org/10.7860/JCDR/2016/19863.8253
Garg P, Chaman C. Apical Periodontitis - Is It Accountable for Cardiovascular Diseases?. J Clin Diagn Res. 2016 Aug;10(8):ZE08-12. doi: 10.7860/JCDR/2016/19863.8253. Epub 2016 Aug 01. PMID: 27656588; PMCID: PMC5028556.
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J Clin Diagn Res. 2016 Aug;10(8):ZE08-12. doi: 10.7860/JCDR/2016/19863.8253. Epub 2016 Aug 01.

Apical Periodontitis - Is It Accountable for Cardiovascular Diseases?.

Journal of clinical and diagnostic research : JCDR

Paridhi Garg, Chandrakar Chaman

Affiliations

  1. Senior Lecturer, Department of Consevative Dentistry and Endodontics, Inderprastha Dental College and Hospital , Sahibabad, Uttar Pradesh, India .
  2. Reader, Department of Consevative Dentistry and Endodontics, Kothiwal Dental College and Research Centre , Moradabad, Uttar Pradesh. India .

PMID: 27656588 PMCID: PMC5028556 DOI: 10.7860/JCDR/2016/19863.8253

Abstract

The aim of this review was to assess the relationship between apical periodontitis and cardiovascular diseases and the predictive factors regarding this association. Cross sectional and observational studies have been included, which are mostly retrospective. A comprehensive search was performed in the Systematic Electronic Databases, PUBMED and MEDLINE from 1919 till September 2014. Articles were also hand searched. From 86 studies identified, all were read and 58 articles which were relevant were included in the text. Some articles were excluded because they were pertaining to periodontology and other systemic disorders. Some were solely animal studies and were thus excluded. Our results suggest an independent association between cardiovascular diseases and apical periodontitis. A causal relationship could not be established since weak parameters of risk have been assessed in the studies, population taken is difficult to compare and other confounding factors have not been ruled out. Only a more focused and better instituted scientific research can determine this association. Establishing a cause and effect relationship between apical periodontitis and cardiovascular diseases can affect the course of treatment of cardiovascular diseases. It is not only of interest from the scientific point of view but also from public health perspective.

Keywords: Bacteraemia; Inflammation; Interleukins; Root canal treatment

References

  1. Oral Surg Oral Med Oral Pathol. 1952 Aug;5(8):799-808 - PubMed
  2. J Am Dent Assoc. 2009 Aug;140(8):1004-12 - PubMed
  3. Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):2394-400 - PubMed
  4. Periodontol 2000. 2000 Jun;23:121-6 - PubMed
  5. Stroke. 1997 Sep;28(9):1724-9 - PubMed
  6. Acta Odontol Scand. 2003 Oct;61(5):257-62 - PubMed
  7. J Dent Res. 2006 Nov;85(11):996-1000 - PubMed
  8. Compend Contin Educ Dent. 2001 Jul;22(3 Spec No):4-11 - PubMed
  9. Int Endod J. 2004 Mar;37(3):167-73 - PubMed
  10. Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):493-8 - PubMed
  11. Circ Res. 2001 Jul 6;89(1):1-2 - PubMed
  12. BMJ. 1989 Mar 25;298(6676):779-81 - PubMed
  13. Mediators Inflamm. 2007;2007:69416 - PubMed
  14. J Periodontol. 1996 Oct;67(10 Suppl):1123-37 - PubMed
  15. J Dent. 2005 Apr;33(4):293-303 - PubMed
  16. Circulation. 1999 Jan 19;99(2):237-42 - PubMed
  17. J Clin Invest. 2002 May;109(10):1351-9 - PubMed
  18. Int J Cardiol. 2011 Apr 1;148(1):4-10 - PubMed
  19. Clin Microbiol Rev. 2000 Oct;13(4):547-58 - PubMed
  20. Bull Tokyo Dent Coll. 2003 Aug;44(3):149-58 - PubMed
  21. J Endod. 1994 May;20(5):225-7 - PubMed
  22. J Endod. 2013 Jan;39(1):62-7 - PubMed
  23. Clin Chem Lab Med. 2000 Feb;38(2):77-85 - PubMed
  24. J Immunol. 2003 Mar 15;170(6):3369-76 - PubMed
  25. Int Endod J. 2003 Nov;36(11):774-9 - PubMed
  26. Am J Pathol. 1979 Sep;96(3):673-706 - PubMed
  27. Periodontol 2000. 2007;44:113-26 - PubMed
  28. J Endod. 2014 Sep;40(9):1400-3 - PubMed
  29. J Endod. 2014 Feb;40(2):164-7 - PubMed
  30. J Can Dent Assoc. 2009 Feb;75(1):35 - PubMed
  31. J Endod. 2013 Oct;39(10):1205-17 - PubMed
  32. J Endod. 2006 Feb;32(2):99-103 - PubMed
  33. Immunity. 2011 Feb 25;34(2):149-62 - PubMed
  34. J Endod. 1992 Sep;18(9):422-6 - PubMed
  35. J Endod. 2009 May;35(5):626-30 - PubMed
  36. Physiol Res. 2009;58(4):481-98 - PubMed
  37. Am J Pathol. 2008 Nov;173(5):1253-64 - PubMed
  38. Int Endod J. 2014 Jul;47(7):615-21 - PubMed
  39. Clin Immunol. 2011 Nov;141(2):152-60 - PubMed
  40. J Dent Res. 1998 Oct;77(10):1764-5 - PubMed
  41. Endocrinology. 1992 Jan;130(1):10-6 - PubMed
  42. J Dent Res. 2007 Apr;86(4):306-19 - PubMed
  43. J Am Dent Assoc. 2006 Oct;137 Suppl:5S-6S - PubMed
  44. J Intern Med. 2002 Oct;252(4):283-94 - PubMed
  45. Atherosclerosis. 2011 Jun;216(2):313-20 - PubMed
  46. Crit Rev Oral Biol Med. 2004 Nov 01;15(6):348-81 - PubMed
  47. Bone. 2003 Jul;33(1):28-37 - PubMed
  48. Z Kardiol. 2000;89 Suppl 9:IX/70-4 - PubMed
  49. BioDrugs. 2012 Aug 1;26(4):217-33 - PubMed
  50. Curr Opin Lipidol. 1999 Oct;10(5):435-41 - PubMed
  51. J Endod. 2003 Nov;29(11):697-700; discussion 696 - PubMed
  52. J Endod. 2010 Nov;36(11):1800-4 - PubMed
  53. Adv Intern Med. 1990;35:45-71 - PubMed
  54. J Clin Periodontol. 2001 Aug;28(8):762-8 - PubMed
  55. J Endod. 2002 Nov;28(11):754-7 - PubMed
  56. Circulation. 2001 May 29;103(21):2531-4 - PubMed
  57. J Periodontol. 2000 Oct;71(10):1554-60 - PubMed
  58. Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):E83-8 - PubMed

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