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Gan G, Preston-Campbell RN, Moeller SJ, et al. Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression. Front Behav Neurosci. 2016;10:179doi: 10.3389/fnbeh.2016.00179.
Gan, G., Preston-Campbell, R. N., Moeller, S. J., Steinberg, J. L., Lane, S. D., Maloney, T., Parvaz, M. A., Goldstein, R. Z., & Alia-Klein, N. (2016). Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression. Frontiers in behavioral neuroscience, 10179. https://doi.org/10.3389/fnbeh.2016.00179
Gan, Gabriela, et al. "Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression." Frontiers in behavioral neuroscience vol. 10 (2016): 179. doi: https://doi.org/10.3389/fnbeh.2016.00179
Gan G, Preston-Campbell RN, Moeller SJ, Steinberg JL, Lane SD, Maloney T, Parvaz MA, Goldstein RZ, Alia-Klein N. Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression. Front Behav Neurosci. 2016 Sep 27;10:179. doi: 10.3389/fnbeh.2016.00179. eCollection 2016. PMID: 27729852; PMCID: PMC5037197.
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Front Behav Neurosci. 2016 Sep 27;10:179. doi: 10.3389/fnbeh.2016.00179. eCollection 2016.

Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression.

Frontiers in behavioral neuroscience

Gabriela Gan, Rebecca N Preston-Campbell, Scott J Moeller, Joel L Steinberg, Scott D Lane, Thomas Maloney, Muhammad A Parvaz, Rita Z Goldstein, Nelly Alia-Klein

Affiliations

  1. Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai New York, NY, USA.
  2. Psychiatry and Neuroscience, Icahn School of Medicine at Mount SinaiNew York, NY, USA; Division of Social and Behavioral Sciences, Lindenwood University-BellevilleBelleville, IL, USA.
  3. Psychiatry, Virginia Commonwealth University Richmond, VA, USA.
  4. Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston Houston, TX, USA.

PMID: 27729852 PMCID: PMC5037197 DOI: 10.3389/fnbeh.2016.00179

Abstract

The propensity for reactive aggression (RA) which occurs in response to provocation has been linked to hyperresponsivity of the mesocorticolimbic reward network in healthy adults. Here, we aim to elucidate the role of the mesocorticolimbic network in clinically significant RA for two competing motivated behaviors, reward-seeking vs. retaliation. 18 male participants performed a variant of the Point-Subtraction Aggression Paradigm (PSAP) during functional magnetic resonance imaging (fMRI). We examined whether RA participants compared with non-aggressive controls would choose to obtain a monetary reward over the opportunity to retaliate against a fictitious opponent, who provoked the participant by randomly stealing money from his earnings. Across all fMRI-PSAP runs, RA individuals vs. controls chose to work harder to earn money but not to retaliate. When engaging in such reward-seeking behavior vs. retaliation in a single fMRI-PSAP run, RA individuals exhibited increased activation in the insular-striatal part of the mesocorticolimbic salience network, and decreased precuneus and ventromedial prefrontal cortex activation compared to controls. Enhanced overall reward-seeking behavior along with an up-regulation of the mesocorticolimbic salience network and a down-regulation of the default-mode network in RA individuals indicate that RA individuals are willing to work more for monetary reward than for retaliation when presented with a choice. Our findings may suggest that the use of positive reinforcement might represent an efficacious intervention approach for the potential reduction of retaliatory behavior in clinically significant RA.

Keywords: intermittent explosive disorder; mesocorticolimbic network; point-subtraction aggression paradigm; reactive aggression; reward; salience

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