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Liu D, Duan S, Zhang J, et al. Aberrant Brain Regional Homogeneity and Functional Connectivity in Middle-Aged T2DM Patients: A Resting-State Functional MRI Study. Front Hum Neurosci. 2016;10:490doi: 10.3389/fnhum.2016.00490.
Liu, D., Duan, S., Zhang, J., Zhou, C., Liang, M., Yin, X., Wei, P., & Wang, J. (2016). Aberrant Brain Regional Homogeneity and Functional Connectivity in Middle-Aged T2DM Patients: A Resting-State Functional MRI Study. Frontiers in human neuroscience, 10490. https://doi.org/10.3389/fnhum.2016.00490
Liu, Daihong, et al. "Aberrant Brain Regional Homogeneity and Functional Connectivity in Middle-Aged T2DM Patients: A Resting-State Functional MRI Study." Frontiers in human neuroscience vol. 10 (2016): 490. doi: https://doi.org/10.3389/fnhum.2016.00490
Liu D, Duan S, Zhang J, Zhou C, Liang M, Yin X, Wei P, Wang J. Aberrant Brain Regional Homogeneity and Functional Connectivity in Middle-Aged T2DM Patients: A Resting-State Functional MRI Study. Front Hum Neurosci. 2016 Sep 27;10:490. doi: 10.3389/fnhum.2016.00490. eCollection 2016. PMID: 27729856; PMCID: PMC5037166.
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Front Hum Neurosci. 2016 Sep 27;10:490. doi: 10.3389/fnhum.2016.00490. eCollection 2016.

Aberrant Brain Regional Homogeneity and Functional Connectivity in Middle-Aged T2DM Patients: A Resting-State Functional MRI Study.

Frontiers in human neuroscience

Daihong Liu, Shanshan Duan, Jiuquan Zhang, Chaoyang Zhou, Minglong Liang, Xuntao Yin, Ping Wei, Jian Wang

Affiliations

  1. Department of Radiology, Southwest Hospital, Third Military Medical University Chongqing, China.
  2. Department of Endocrinology, Southwest Hospital, Third Military Medical University Chongqing, China.

PMID: 27729856 PMCID: PMC5037166 DOI: 10.3389/fnhum.2016.00490

Abstract

Type 2 diabetes mellitus (T2DM) has been associated with cognitive impairment. However, its neurological mechanism remains elusive. Combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, the present study aimed to investigate brain functional alterations in middle-aged T2DM patients, which could provide complementary information for the neural substrates underlying T2DM-associated brain dysfunction. Twenty-five T2DM patients and 25 healthy controls were involved in neuropsychological testing and structural and resting-state functional magnetic resonance imaging (rs-fMRI) data acquisition. ReHo analysis was conducted to determine the peak coordinates of brain regions with abnormal local brain activity synchronization. Then, the identified brain regions were considered as seeds, and FC between these brain regions and global voxels was computed. Finally, the potential correlations between the imaging indices and neuropsychological data were also explored. Compared with healthy controls, T2DM patients exhibited higher ReHo values in the anterior cingulate gyrus (ACG) and lower ReHo in the right fusiform gyrus (FFG), right precentral gyrus (PreCG) and right medial orbit of the superior frontal gyrus (SFG). Considering these areas as seed regions, T2DM patients displayed aberrant FC, mainly in the frontal and parietal lobes. The pattern of FC alterations in T2DM patients was characterized by decreased connectivity and positive to negative or negative to positive converted connectivity. Digital Span Test (DST) forward scores revealed significant correlations with the ReHo values of the right PreCG (ρ = 0.527,

Keywords: cognitive impairment; functional connectivity; regional homogeneity; resting-state functional magnetic resonance imaging; type 2 diabetes mellitus

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