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Peek MC, Kovacs T, Baker R, et al. Is blue dye still required during sentinel lymph node biopsy for breast cancer?. Ecancermedicalscience. 2016;10:674doi: 10.3332/ecancer.2016.674.
Peek, M. C., Kovacs, T., Baker, R., Hamed, H., Kothari, A., & Douek, M. (2016). Is blue dye still required during sentinel lymph node biopsy for breast cancer?. Ecancermedicalscience, 10674. https://doi.org/10.3332/ecancer.2016.674
Peek, Mirjam Cl, et al. "Is blue dye still required during sentinel lymph node biopsy for breast cancer?." Ecancermedicalscience vol. 10 (2016): 674. doi: https://doi.org/10.3332/ecancer.2016.674
Peek MC, Kovacs T, Baker R, Hamed H, Kothari A, Douek M. Is blue dye still required during sentinel lymph node biopsy for breast cancer?. Ecancermedicalscience. 2016 Sep 19;10:674. doi: 10.3332/ecancer.2016.674. eCollection 2016. PMID: 27729939; PMCID: PMC5045297.
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Ecancermedicalscience. 2016 Sep 19;10:674. doi: 10.3332/ecancer.2016.674. eCollection 2016.

Is blue dye still required during sentinel lymph node biopsy for breast cancer?.

Ecancermedicalscience

Mirjam Cl Peek, Tibor Kovacs, Rose Baker, Hisham Hamed, Ash Kothari, Michael Douek

Affiliations

  1. Division of Cancer Studies, King's College London, Guy's Hospital Campus, Great Maze Pond, London SE1 9RT, UK; Guy's and St. Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
  2. Guy's and St. Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
  3. School of Business, 612, Maxwell Bldg, University of Salford, Salford M5 4WT, UK.

PMID: 27729939 PMCID: PMC5045297 DOI: 10.3332/ecancer.2016.674

Abstract

BACKGROUND: In early breast cancer, the optimal technique for sentinel lymph node biopsy (SLNB) is the combined technique (radioisotope and Patent Blue V) which achieves high identification rates. Despite this, many centres have decided to stop using blue dye due to blue-dye-related complications (tattoo, anaphylaxis). We evaluated the SLNB identification rate using the combined technique with and without Patent Blue V and the blue-dye-related complication rates.

METHODS: Clinical and histological data were analysed on patients undergoing SLNB between March 2014 and April 2015. SLNB was performed following standard hospital protocols using the combined technique.

RESULTS: A total of 208 patients underwent SLNB and 160 patients (342 nodes) with complete operation notes were available for final analysis. The identification rate with the combined technique was 98.8% (

CONCLUSION: The combined technique should continue be the preferred technique for SLNB and should be standardised. Radioisotope alone (but not blue dye alone) has comparable sentinel node identification rates in experienced hands. National guidelines are required to optimise operative documentation.

Keywords: breast cancer; patent blue; radioisotope; sentinel lymph node biopsy

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