Indian J Endocrinol Metab. 2016 Sep-Oct;20(5):656-661. doi: 10.4103/2230-8210.190550.

High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk.

Indian journal of endocrinology and metabolism

Stephen R James, Lopamudra Ray, Kandasamy Ravichandran, Sunil Kumar Nanda

PMID: 27730076 PMCID: PMC5040046 DOI: 10.4103/2230-8210.190550

Abstract

BACKGROUND: A controversy exists regarding the association between subclinical hypothyroidism (SH) and dyslipidemia. Moreover, studies on lipid ratios and atherogenic index of plasma (AIP) in SH are rare, particularly in the Indian scenario.

AIM: This study aimed to investigate abnormalities in conventional lipid profile, lipid ratios, and AIP in SH and attempted to correlate thyroid stimulating hormone (TSH) and AIP in SH.

MATERIALS AND METHODS: In this retrospective analysis of patient records of SH subjects and euthyroid subjects, age, free triiodothyronine, free thyroxine, TSH, total cholesterol, triglycerides, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol, lipid ratios, and AIP were compared between the two groups. The correlation of TSH and AIP in SH was studied. Spearman's correlation, Mann-Whitney U-test and logistic regression analysis were performed.

RESULTS: Triglyceride, triglyceride/HDL-C, and AIP were significantly higher in SH as compared to euthyroid group, but there was no correlation between TSH and AIP in SH. AIP emerged as the significant single factor associated with SH in multiple logistic regressions.

CONCLUSION: The positive association of dyslipidemia and SH indicates a need for regular screening of these patients to enable early diagnosis and treatment of dyslipidemia. Even in patients who have a normal conventional lipid profile, lipid ratios, and AIP have to be calculated for better assessment of atherogenic risk.

Keywords: Atherogenic index of plasma; dyslipidemia; lipid profile; lipid ratios; subclinical hypothyroidism

References

1. Clin Endocrinol (Oxf). 2009 Jul;71(1):130-6 - PubMed
2. Arch Physiol Biochem. 2013 Feb;119(1):27-31 - PubMed
3. Hormones (Athens). 2013 Oct-Dec;12(4):495-506 - PubMed
4. Thyroid. 2004 Aug;14(8):605-9 - PubMed
5. Clin Endocrinol (Oxf). 2013 May;78(5):777-82 - PubMed
6. Angiology. 2003 Sep-Oct;54(5):569-76 - PubMed
7. Med Sci Monit. 2014 Aug 14;20:1432-41 - PubMed
8. J Clin Endocrinol Metab. 2008 Mar;93(3):888-94 - PubMed
9. Clin Endocrinol (Oxf). 2006 Mar;64(3):323-9 - PubMed
10. Clin Biochem. 2001 Oct;34(7):583-8 - PubMed
11. Clin Chem. 2004 Jul;50(7):1113-5 - PubMed
12. Arch Intern Med. 2000 Feb 28;160(4):526-34 - PubMed
13. Endocr J. 2008 May;55(2):381-9 - PubMed
14. J Clin Endocrinol Metab. 2000 Sep;85(9):2993-3001 - PubMed
15. Ann Fam Med. 2004 Jul-Aug;2(4):351-5 - PubMed
16. Mayo Clin Proc. 2009;84(1):65-71 - PubMed
17. J Clin Invest. 1972 Aug;51(8):2103-14 - PubMed
18. Thyroid. 2000 Aug;10(8):665-79 - PubMed
19. J Lipid Res. 1981 Feb;22(2):323-38 - PubMed
20. Vnitr Lek. 2006 Jan;52(1):64-71 - PubMed
21. Korean J Intern Med. 2011 Dec;26(4):432-9 - PubMed
22. J Clin Diagn Res. 2013 Oct;7(10):2122-5 - PubMed
23. Ann Nutr Metab. 1999;43(6):374-9 - PubMed
24. Int J Endocrinol Metab. 2014 Jul 01;12(3):e17496 - PubMed
25. Arch Physiol Biochem. 2012 May;118(2):43-6 - PubMed
26. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2591-5 - PubMed
27. Clin Biochem. 2011 Oct;44(14-15):1214-7 - PubMed
28. J Am Geriatr Soc. 2010 Aug;58(8):1613-4 - PubMed
29. Open Cardiovasc Med J. 2011;5:76-84 - PubMed
30. Eur J Endocrinol. 2001 Dec;145(6):705-10 - PubMed
31. Int J Obes Relat Metab Disord. 2000 Jun;24 Suppl 2:S109-12 - PubMed
32. J Clin Endocrinol Metab. 2002 Apr;87(4):1533-8 - PubMed

Publication Types

• Journal Article