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McDaniels-Davidson CR, Kritz-Silverstein D, Huang MH, et al. The association between bone turnover markers and kyphosis in community-dwelling older adults. Bone Rep. 2016;5:57-61doi: 10.1016/j.bonr.2016.04.001.
McDaniels-Davidson, C. R., Kritz-Silverstein, D., Huang, M. H., Laughlin, G. A., Johnson, S., Haapalahti, J., Schneider, D. L., Barrett-Connor, E., & Kado, D. M. (2016). The association between bone turnover markers and kyphosis in community-dwelling older adults. Bone reports, 557-61. https://doi.org/10.1016/j.bonr.2016.04.001
McDaniels-Davidson, Corinne R, et al. "The association between bone turnover markers and kyphosis in community-dwelling older adults." Bone reports vol. 5 (2016): 57-61. doi: https://doi.org/10.1016/j.bonr.2016.04.001
McDaniels-Davidson CR, Kritz-Silverstein D, Huang MH, Laughlin GA, Johnson S, Haapalahti J, Schneider DL, Barrett-Connor E, Kado DM. The association between bone turnover markers and kyphosis in community-dwelling older adults. Bone Rep. 2016 Apr 08;5:57-61. doi: 10.1016/j.bonr.2016.04.001. eCollection 2016 Dec. PMID: 27868084; PMCID: PMC4926834.
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Bone Rep. 2016 Apr 08;5:57-61. doi: 10.1016/j.bonr.2016.04.001. eCollection 2016 Dec.

The association between bone turnover markers and kyphosis in community-dwelling older adults.

Bone reports

Corinne R McDaniels-Davidson, Donna Kritz-Silverstein, Mei-Hua Huang, Gail A Laughlin, Sarah Johnson, Jouko Haapalahti, Diane L Schneider, Elizabeth Barrett-Connor, Deborah M Kado

Affiliations

  1. San Diego State University/University of California, San Diego Joint Doctoral Program in Public Health (Epidemiology), 9500 Gilman Drive, MC 0725, La Jolla, CA 92093, United States.
  2. Department of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego, CA, United States.
  3. Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
  4. SPD Development Company Limited, Bedford, UK.
  5. JouZeNet Consulting Limited, Kempele, Finland.
  6. 4BoneHealth, La Jolla, CA, United States.

PMID: 27868084 PMCID: PMC4926834 DOI: 10.1016/j.bonr.2016.04.001

Abstract

PURPOSE: Hyperkyphosis, accentuated curvature of the thoracic spine, is often attributed to osteoporosis, yet its underlying pathophysiology is not well understood. Bone turnover markers (BTM) reflect the dynamic process of bone formation and resorption. This study examined the association between serum BTM levels and kyphosis in community-dwelling older adults.

METHODS: Between 2003 and 2006, 760 men and women in the Rancho Bernardo Study age 60 and older had blood drawn and kyphosis measured. Fasting serum was assayed for N-telopeptide (NTX) and procollagen type 1 n-terminal propeptide (P1NP), markers of bone resorption and formation, respectively. Participants requiring two or more 1.7 cm blocks under their head to achieve a neutral supine position were classified as having accentuated kyphosis. Analyses were stratified by sex and use of estrogen therapy (ET). Odds of accentuated kyphosis were calculated for each standard deviation increase in log-transformed BTM.

RESULTS: Mean age was 75 years. Overall, 51% of 341 non-ET using women, 41% of 111 ET-using women, and 75% of 308 men had accentuated kyphosis. In adjusted models, higher P1NP and NTX were associated with decreased odds of accentuated kyphosis in non-ET using women (P1NP: OR = 0.78 [95% CI, 0.58-0.92]; NTX: OR = 0.68 [95% CI, 0.54-0.86]), but not in men or ET-using women (

CONCLUSIONS: The selective association of higher bone turnover with reduced odds of accentuated kyphosis in non-ET using women suggests that elevated BTM were associated with a lower likelihood of hyperkyphosis only in the low estrogen/high BTM environment characteristic of postmenopausal women who are not using ET.

Keywords: BTM, bone turnover markers; Bone remodeling; Bone turnover; ET, estrogen therapy; Hyperkyphosis; Kyphosis; NTX; NTX, N-telopeptide; P1NP; P1NP, procollagen type 1 n-terminal propeptide; SOF, Study of Osteoporotic Fractures

Conflict of interest statement

Dr. Sarah Johnson is a Senior Research Scientist at SPD Development Company Limited, the entity that performed the NTX assays.

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