Display options
Cite
Vasovic M, Gajovic N, Brajkovic D, et al. The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review. Cent Eur J Immunol. 2016;41(3):302-310doi: 10.5114/ceji.2016.63131.
Vasovic, M., Gajovic, N., Brajkovic, D., Jovanovic, M., Zdravkovaic, N., & Kanjevac, T. (2016). The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review. Central-European journal of immunology, 41(3), 302-310. https://doi.org/10.5114/ceji.2016.63131
Vasovic, Miroslav, et al. "The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review." Central-European journal of immunology vol. 41,3 (2016): 302-310. doi: https://doi.org/10.5114/ceji.2016.63131
Vasovic M, Gajovic N, Brajkovic D, Jovanovic M, Zdravkovaic N, Kanjevac T. The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review. Cent Eur J Immunol. 2016;41(3):302-310. doi: 10.5114/ceji.2016.63131. Epub 2016 Oct 25. PMID: 27833449; PMCID: PMC5099388.
Copy Download .nbib Format: NLM
Share it on

Cent Eur J Immunol. 2016;41(3):302-310. doi: 10.5114/ceji.2016.63131. Epub 2016 Oct 25.

The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review.

Central-European journal of immunology

Miroslav Vasovic, Nevena Gajovic, Denis Brajkovic, Marina Jovanovic, Natasa Zdravkovaic, Tatjana Kanjevac

Affiliations

  1. Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Serbia.
  2. Center for Molecular Medicine and Stem Cells Research, Faculty of Medical Sciences, University of Kragujevac, Serbia.
  3. Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Serbia.

PMID: 27833449 PMCID: PMC5099388 DOI: 10.5114/ceji.2016.63131

Abstract

Inflammatory bowel diseases (IBDs) are chronic, relapsing inflammatory diseases characterized by exacerbations and remissions of the gastrointestinal tract, clinically manifested as Crohn's disease and ulcerative colitis. The etiology of IBDs is considered to be multi factorial, comprising environmental, immune, microbial and genetic factors. Clinical signs may include abdominal pain, frequent bloody diarrheas, mucorrhea, vomiting, fever, fatigue or weight loss. Changes in the oral cavity often precede intestinal symptoms. Inflammatory bowel disease leads to a significant deterioration of oral health, which indicates that cooperation between the dentist and the gastroenterologist is necessary when considering patients' welfare. Patients with IBD have an altered immune response, but microorganisms of the oral cavity may also be responsible for its modification. This review paper discusses the correlation between the immune system and inflammatory bowel disease manifestations in the oral cavity.

Keywords: dental management; immune system; inflammatory bowel diseases; oral disease; oral health

References

  1. Gastroenterology. 1995 May;108(5):1434-44 - PubMed
  2. Cytokine. 2008 Feb;41(2):144-9 - PubMed
  3. J Clin Periodontol. 2008 Jun;35(6):555-60 - PubMed
  4. Inflamm Res. 2014 Nov;63(11):943-50 - PubMed
  5. Arch Dermatol. 1999 Apr;135(4):439-42 - PubMed
  6. Clin Oral Implants Res. 2013 Feb;24(2):224-9 - PubMed
  7. N Engl J Med. 2002 Aug 8;347(6):417-29 - PubMed
  8. Pol Arch Med Wewn. 2012;122(5):200-8 - PubMed
  9. Arch Biochem Biophys. 2010 Nov 1;503(1):54-65 - PubMed
  10. J Gastroenterol. 1995 Nov;30 Suppl 8:56-60 - PubMed
  11. J Dent Res. 2013 Jun;92(6):485-91 - PubMed
  12. Scand J Gastroenterol. 1983 Nov;18(8):999-1002 - PubMed
  13. Gut. 2012 Dec;61(12):1693-700 - PubMed
  14. Inflamm Bowel Dis. 2011 Sep;17(9):1971-8 - PubMed
  15. J Allergy Clin Immunol. 2009 May;123(5):1004-11 - PubMed
  16. Dig Dis Sci. 2011 Jan;56(1):170-5 - PubMed
  17. J Clin Invest. 2004 May;113(10):1490-7 - PubMed
  18. PLoS One. 2013;8(1):e54562 - PubMed
  19. Gut. 2002 Feb;50(2):146-7 - PubMed
  20. Oral Dis. 2000 May;6(3):138-51 - PubMed
  21. Clin Rev Allergy Immunol. 2005 Jun;28(3):187-96 - PubMed
  22. Gastroenterology. 2013 Dec;145(6):1380-91.e1 - PubMed
  23. Pediatrics. 2005 Sep;116(3):e439-44 - PubMed
  24. Gastroenterology. 2000 Dec;119(6):1461-72 - PubMed
  25. Dig Dis Sci. 2006 Nov;51(11):2062-3 - PubMed
  26. J Clin Periodontol. 2004 Aug;31(8):671-9 - PubMed
  27. Circulation. 2008 Jun 17;117(24):3118-25 - PubMed
  28. J Clin Periodontol. 2007 Jul;34(7):610-7 - PubMed
  29. Oral Dis. 2014 Oct;20(7):700-6 - PubMed
  30. Scand J Gastroenterol. 2005 Dec;40(12):1444-8 - PubMed
  31. J Crohns Colitis. 2014 Aug;8(8):726-34 - PubMed
  32. Gastroenterology. 1997 Aug;113(2):383-9 - PubMed
  33. Oral Surg Oral Med Oral Pathol. 1989 Mar;67(3):286-90 - PubMed
  34. Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1020-9 - PubMed
  35. Histol Histopathol. 2000 Jan;15(1):167-72 - PubMed
  36. J Clin Invest. 2006 May;116(5):1310-6 - PubMed
  37. Gut. 2001 Jul;49(1):42-6 - PubMed
  38. Inflamm Bowel Dis. 2005 Aug;11(8):707-12 - PubMed
  39. Gastroenterology. 2008 Feb;134(2):577-94 - PubMed
  40. Eur J Immunol. 2012 May;42(5):1337-53 - PubMed
  41. Immunotherapy. 2011 Nov;3(11):1341-52 - PubMed
  42. J Periodontal Res. 2011 Feb;46(1):141-6 - PubMed
  43. Nat Clin Pract Gastroenterol Hepatol. 2006 Jul;3(7):390-407 - PubMed
  44. World J Gastroenterol. 2004 Mar 1;10(5):620-5 - PubMed
  45. Oral Surg Oral Med Oral Pathol. 1983 Apr;55(4):363-73 - PubMed
  46. Microbes Infect. 2009 Apr;11(5):589-93 - PubMed
  47. J Am Acad Dermatol. 1994 Aug;31(2 Pt 2):336-41 - PubMed
  48. N Engl J Med. 2001 Oct 11;345(15):1098-104 - PubMed
  49. Nutrition. 1996 Mar;12(3):151-8 - PubMed
  50. Gastroenterology. 2000 Dec;119(6):1473-82 - PubMed
  51. J Periodontal Res. 1998 May;33(4):212-25 - PubMed
  52. Gastroenterology. 2010 Apr;138(4):1384-94, 1394.e1-2 - PubMed
  53. J Clin Periodontol. 2008 Jan;35(1):51-7 - PubMed
  54. Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii87-90 - PubMed
  55. Clin Rev Allergy Immunol. 2010 Feb;38(1):20-31 - PubMed
  56. J Clin Microbiol. 2004 Jan;42(1):198-202 - PubMed
  57. Dig Dis. 2003;21(3):252-7 - PubMed
  58. Drugs. 2012 Dec 24;72(18):2333-49 - PubMed
  59. Braz J Med Biol Res. 2015 Feb;48(2):96-107 - PubMed
  60. Int J Immunopathol Pharmacol. 2014 Jan-Mar;27(1 Suppl):11-32 - PubMed
  61. J Periodontol. 2010 Apr;81(4):535-45 - PubMed
  62. Gut. 2003 Jan;52(1):65-70 - PubMed
  63. Acta Chir Scand. 1982;148(6):531-4 - PubMed
  64. J Med Microbiol. 2007 Oct;56(Pt 10):1413-5 - PubMed
  65. Nature. 2007 Jul 26;448(7152):427-34 - PubMed
  66. J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S12-7 - PubMed
  67. Semin Immunol. 2007 Dec;19(6):383-93 - PubMed
  68. Oral Surg Oral Med Oral Pathol. 1991 Dec;72(6):689-92 - PubMed
  69. Int Dent J. 2002 Jun;52(3):163-72 - PubMed
  70. Lancet. 2012 Nov 3;380(9853):1590-605 - PubMed
  71. Expert Rev Clin Immunol. 2012 Feb;8(2):161-8 - PubMed
  72. J Clin Periodontol. 2011 Mar;38 Suppl 11:36-43 - PubMed
  73. Inflamm Bowel Dis. 2010 Feb;16(2):332-7 - PubMed
  74. Inflamm Bowel Dis. 2013 Dec;19(13):2768-77 - PubMed
  75. Int J Med Sci. 2014 Jul 02;11(9):936-47 - PubMed
  76. J Periodontal Res. 2012 Jun;47(3):293-8 - PubMed
  77. Medicine (Baltimore). 1976 Sep;55(5):401-12 - PubMed
  78. Mol Immunol. 2009 Nov;47(1):3-7 - PubMed
  79. PLoS One. 2014 Mar 07;9(3):e91059 - PubMed
  80. Pharm Res. 2004 Nov;21(11):2072-8 - PubMed
  81. N Engl J Med. 1996 Mar 28;334(13):841-8 - PubMed
  82. J Clin Periodontol. 2006 Jul;33(7):478-84 - PubMed
  83. Annu Rev Med. 2007;58:433-44 - PubMed
  84. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Nov;108(5):e1-10 - PubMed
  85. Ann N Y Acad Sci. 2007 Jan;1095:305-14 - PubMed
  86. Sci Rep. 2012;2:332 - PubMed
  87. Gut. 2000 Mar;46(3):344-9 - PubMed
  88. Cancer Detect Prev. 2005;29(1):42-5 - PubMed
  89. Gastroenterology. 2011 May;140(6):1704-12 - PubMed
  90. Gene Ther. 2008 Sep;15(17):1200-9 - PubMed
  91. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Jan;87(1):12-4 - PubMed
  92. Inflamm Bowel Dis. 2013 Jan;19(1):141-50 - PubMed
  93. Clin Exp Dermatol. 1997 Jan;22(1):44-5 - PubMed
  94. World J Gastroenterol. 2013 Jul 7;19(25):3931-41 - PubMed
  95. PLoS One. 2012;7(5):e38217 - PubMed
  96. Dig Dis Sci. 2010 Aug;55(8):2194-202 - PubMed

Publication Types