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El Massioui N, Lamirault C, Yagüe S, et al. Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease. Front Behav Neurosci. 2016;10:204doi: 10.3389/fnbeh.2016.00204.
El Massioui, N., Lamirault, C., Yagüe, S., Adjeroud, N., Garces, D., Maillard, A., Tallot, L., Yu-Taeger, L., Riess, O., Allain, P., Nguyen, H. P., von Hörsten, S., & Doyère, V. (2016). Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease. Frontiers in behavioral neuroscience, 10204. https://doi.org/10.3389/fnbeh.2016.00204
El Massioui, Nicole, et al. "Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease." Frontiers in behavioral neuroscience vol. 10 (2016): 204. doi: https://doi.org/10.3389/fnbeh.2016.00204
El Massioui N, Lamirault C, Yagüe S, Adjeroud N, Garces D, Maillard A, Tallot L, Yu-Taeger L, Riess O, Allain P, Nguyen HP, von Hörsten S, Doyère V. Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease. Front Behav Neurosci. 2016 Oct 26;10:204. doi: 10.3389/fnbeh.2016.00204. eCollection 2016. PMID: 27833538; PMCID: PMC5080295.
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Front Behav Neurosci. 2016 Oct 26;10:204. doi: 10.3389/fnbeh.2016.00204. eCollection 2016.

Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease.

Frontiers in behavioral neuroscience

Nicole El Massioui, Charlotte Lamirault, Sara Yagüe, Najia Adjeroud, Daniel Garces, Alexis Maillard, Lucille Tallot, Libo Yu-Taeger, Olaf Riess, Philippe Allain, Huu Phuc Nguyen, Stephan von Hörsten, Valérie Doyère

Affiliations

  1. Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Centre National de la Recherche Scientifique (CNRS) Université Paris Sud, Université Paris Saclay Orsay, France.
  2. Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Centre National de la Recherche Scientifique (CNRS) Université Paris Sud, Université Paris SaclayOrsay, France; Neuropsychological Unit, Department of Neurology, CHU AngersFrance.
  3. The Graduate Center, City University of New York (CUNY) New York, NY, USA.
  4. Institute of Medical Genetics and Applied Genomics, University of TuebingenTuebingen, Germany; Center for Rare Diseases, University of TuebingenTuebingen, Germany.
  5. Neuropsychological Unit, Department of Neurology, CHU Angers France.
  6. Experimental Therapy, Franz Penzoldt Center, Friedrich-Alexander University, Erlangen-Nürnberg Germany.

PMID: 27833538 PMCID: PMC5080295 DOI: 10.3389/fnbeh.2016.00204

Abstract

Cognitive deficits associated with Huntington disease (HD) are generally dominated by executive function disorders often associated with disinhibition and impulsivity/compulsivity. Few studies have directly examined symptoms and consequences of behavioral disinhibition in HD and its relation with decision-making. To assess the different forms of impulsivity in a transgenic model of HD (tgHD rats), two tasks assessing cognitive/choice impulsivity were used: risky decision-making with a rat gambling task (RGT) and intertemporal choices with a delay discounting task (DD). To assess waiting or action impulsivity the differential reinforcement of low rate of responding task (DRL) was used. In parallel, the volume as well as cellular activity of the amygdala was analyzed. In contrast to WT rats, 15 months old tgHD rats exhibited a poor efficiency in the RGT task with difficulties to choose advantageous options, a steep DD curve as delays increased in the DD task and a high rate of premature and bursts responses in the DRL task. tgHD rats also demonstrated a concomitant and correlated presence of both action and cognitive/choice impulsivity in contrast to wild type (WT) animals. Moreover, a reduced volume associated with an increased basal cellular activity of the central nucleus of amygdala indicated a dysfunctional amygdala in tgHD rats, which could underlie inhibitory dyscontrol. In conclusion, tgHD rats are a good model for impulsivity disorder that could be used more widely to identify potential pharmacotherapies to treat these invasive symptoms in HD.

Keywords: DRL; Huntington disease; decision-making; delay discounting; gambling task; impulsivity

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