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Front Pharmacol. 2016 Oct 26;7:393. doi: 10.3389/fphar.2016.00393. eCollection 2016.

Anti-inflammatory Effects of Herbal Preparations STW5 and STW5-II in Cytokine-Challenged Normal Human Colon Cells.

Frontiers in pharmacology

Mathias Schneider, Thomas Efferth, Heba Abdel-Aziz

Affiliations

  1. Department of Pharmaceutical Biology, Johannes Gutenberg University, Mainz Germany.
  2. Department of Pharmaceutical Biology, Johannes Gutenberg University, MainzGermany; Medical and Clinical Affairs Phytomedicines, Steigerwald Arzneimittelwerk GmbH, Bayer Consumer Health, DarmstadtGermany.

PMID: 27833553 PMCID: PMC5080345 DOI: 10.3389/fphar.2016.00393

Abstract

Inflammatory bowel diseases (IBD) are chronic relapsing intestinal disorders characterized by up-regulation of pro-inflammatory cytokines followed by invasion of immune cells to the intestinal lamina propria. Standard therapies consist of anti-inflammatory or immunosuppressive drugs. Since clinical efficiency is not satisfactory and the established drugs have massive side effects, new strategies to treat IBD are required. Herein, we investigate the protective effect of the fixed combination herbal preparations STW5 and STW5-II and the contribution of the corresponding single components in an

Keywords: Inflammatory bowel disease; Phytotherapy; Proteomics

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