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Corrie TJ, Ball LT, Russell CA, et al. Au-Catalyzed Biaryl Coupling To Generate 5- to 9-Membered Rings: Turnover-Limiting Reductive Elimination versus π-Complexation. J Am Chem Soc. 2016;139(1):245-254doi: 10.1021/jacs.6b10018.
Corrie, T. J., Ball, L. T., Russell, C. A., & Lloyd-Jones, G. C. (2017). Au-Catalyzed Biaryl Coupling To Generate 5- to 9-Membered Rings: Turnover-Limiting Reductive Elimination versus π-Complexation. Journal of the American Chemical Society, 139(1), 245-254. https://doi.org/10.1021/jacs.6b10018
Corrie, Tom J A, et al. "Au-Catalyzed Biaryl Coupling To Generate 5- to 9-Membered Rings: Turnover-Limiting Reductive Elimination versus π-Complexation." Journal of the American Chemical Society vol. 139,1 (2017): 245-254. doi: https://doi.org/10.1021/jacs.6b10018
Corrie TJ, Ball LT, Russell CA, Lloyd-Jones GC. Au-Catalyzed Biaryl Coupling To Generate 5- to 9-Membered Rings: Turnover-Limiting Reductive Elimination versus π-Complexation. J Am Chem Soc. 2017 Jan 11;139(1):245-254. doi: 10.1021/jacs.6b10018. Epub 2016 Dec 29. PMID: 27936749.
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J Am Chem Soc. 2017 Jan 11;139(1):245-254. doi: 10.1021/jacs.6b10018. Epub 2016 Dec 29.

Au-Catalyzed Biaryl Coupling To Generate 5- to 9-Membered Rings: Turnover-Limiting Reductive Elimination versus π-Complexation.

Journal of the American Chemical Society

Tom J A Corrie, Liam T Ball, Christopher A Russell, Guy C Lloyd-Jones

Affiliations

  1. EaStChem, University of Edinburgh , Joseph Black Building, David Brewster Road, Edinburgh EH9 3FJ, U.K.
  2. School of Chemistry, University of Bristol , Cantock's Close, Bristol BS8 1TS, U.K.

PMID: 27936749 DOI: 10.1021/jacs.6b10018

Abstract

The intramolecular gold-catalyzed arylation of arenes by aryl-trimethylsilanes has been investigated from both mechanistic and preparative aspects. The reaction generates 5- to 9-membered rings, and of the 44 examples studied, 10 include a heteroatom (N, O). Tethering of the arene to the arylsilane provides not only a tool to probe the impact of the conformational flexibility of Ar-Au-Ar intermediates, via systematic modulation of the length of aryl-aryl linkage, but also the ability to arylate neutral and electron-poor arenes-substrates that do not react at all in the intermolecular process. Rendering the arylation intramolecular also results in phenomenologically simpler reaction kinetics, and overall these features have facilitated a detailed study of linear free energy relationships, kinetic isotope effects, and the first quantitative experimental data on the effects of aryl electron demand and conformational freedom on the rate of reductive elimination from diaryl-gold(III) species. The turnover-limiting step for the formation of a series of fluorene derivatives is sensitive to the reactivity of the arene and changes from reductive elimination to π-complexation for arenes bearing strongly electron-withdrawing substituents (σ > 0.43). Reductive elimination is accelerated by electron-donating substituents (ρ = -2.0) on one or both rings, with the individual σ-values being additive in nature. Longer and more flexible tethers between the two aryl rings result in faster reductive elimination from Ar-Au(X)-Ar and lead to the π-complexation of the arene by Ar-AuX

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