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Menon B, Ramalingam K, Conjeevaram J, et al. Role of brain natriuretic peptide as a novel prognostic biomarker in acute ischemic stroke. Ann Indian Acad Neurol. 2016;19(4):462-466doi: 10.4103/0972-2327.194422.
Menon, B., Ramalingam, K., Conjeevaram, J., & Munisusmitha, K. (2016). Role of brain natriuretic peptide as a novel prognostic biomarker in acute ischemic stroke. Annals of Indian Academy of Neurology, 19(4), 462-466. https://doi.org/10.4103/0972-2327.194422
Menon, Bindu, et al. "Role of brain natriuretic peptide as a novel prognostic biomarker in acute ischemic stroke." Annals of Indian Academy of Neurology vol. 19,4 (2016): 462-466. doi: https://doi.org/10.4103/0972-2327.194422
Menon B, Ramalingam K, Conjeevaram J, Munisusmitha K. Role of brain natriuretic peptide as a novel prognostic biomarker in acute ischemic stroke. Ann Indian Acad Neurol. 2016 Oct-Dec;19(4):462-466. doi: 10.4103/0972-2327.194422. PMID: 27994354; PMCID: PMC5144466.
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Ann Indian Acad Neurol. 2016 Oct-Dec;19(4):462-466. doi: 10.4103/0972-2327.194422.

Role of brain natriuretic peptide as a novel prognostic biomarker in acute ischemic stroke.

Annals of Indian Academy of Neurology

Bindu Menon, Krishnana Ramalingam, Jyoti Conjeevaram, K Munisusmitha

Affiliations

  1. Department of Neurology, Apollo Speciality Hospitals, Nellore, Andhra Pradesh, India.
  2. Department of Biochemistry, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India.
  3. Department of Community Medicine, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India.

PMID: 27994354 PMCID: PMC5144466 DOI: 10.4103/0972-2327.194422

Abstract

AIM: We investigated to study the prognostic importance of brain natriuretic peptide (BNP) in ischemic stroke.

MATERIALS AND METHODS: We prospectively enrolled 100 patients with acute ischemic stroke and measured plasma BNP levels and compared with age- and sex-matched healthy controls. Risk factors, biochemical parameters, lipid profile, carotid and vertebral Doppler, imaging, and cardiac evaluation were done. Stroke severity was assessed by the National Institutes of Health Stroke Scale (NIHSS) score on admission and functional disability by Barthel Index (BI) at 3 months. Ischemic stroke subtype was classified according to the Oxfordshire Community Stroke Project (OCSP). Data were entered in MS Excel, and appropriate statistical analysis was done using the SPSS software version 21.0. A

RESULTS: Mean age of patients was 55.17 ± 11.37 years with a male:female ratio 3:1. OCSP showed total anterior circulation infarct (TACI) 35, partial anterior circulation infarct 9, lacunar infarct 12, and posterior circulation infarct 44. NIHSS on admission was average 10 ± 7 and BI was 57 ± 30. BNP in patients (435 ng/ml) was very high as compared to controls (<60 ng/ml) (

CONCLUSION: Plasma BNP levels was significantly elevated in patients with ischemic stroke. Our study concludes that high BNP levels are seen in large anterior circulation stroke and is a predictor for the poor functional outcome at 3 months. Determination of BNP levels as a biomarker could be helpful in predicting the outcome in stroke patients.

Keywords: Brain natriuretic peptide; prognosis; stroke

Conflict of interest statement

There are no conflicts of interest.

References

  1. Stroke. 2006 Jan;37(1):263-6 - PubMed
  2. Hypertens Res. 2008 Sep;31(9):1695-702 - PubMed
  3. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S41-4 - PubMed
  4. Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H12-20 - PubMed
  5. Peptides. 1992 Jan-Feb;13(1):121-3 - PubMed
  6. J Stroke Cerebrovasc Dis. 2015 Oct;24(10):2207-12 - PubMed
  7. J Neurol Neurosurg Psychiatry. 2003 Jun;74(6):725-7 - PubMed
  8. N Engl J Med. 2001 Oct 4;345(14):1014-21 - PubMed
  9. Lancet. 1991 Jun 22;337(8756):1521-6 - PubMed
  10. Stroke. 2005 May;36(5):1016-20 - PubMed
  11. Stroke. 1996 Dec;27(12):2331-6 - PubMed
  12. Intensive Care Med. 2007 Sep;33(9):1587-93 - PubMed
  13. Stroke. 1982 Nov-Dec;13(6):838-42 - PubMed
  14. Am J Cardiol. 2009 Jul 15;104(2):287-91 - PubMed
  15. J Neurol Sci. 2010 Mar 15;290(1-2):37-40 - PubMed
  16. JAMA. 2013 Jul 3;310(1):66-74 - PubMed
  17. Neurology. 2008 Jun 10;70(24 Pt 2):2371-7 - PubMed
  18. Circulation. 1998 May 19;97(19):1921-9 - PubMed
  19. J Clin Invest. 1991 Apr;87(4):1402-12 - PubMed
  20. J Lab Clin Med. 1999 Nov;134(5):437-44 - PubMed
  21. J Stroke Cerebrovasc Dis. 2015 Feb;24(2):485-91 - PubMed
  22. N Engl J Med. 2002 Jul 18;347(3):161-7 - PubMed
  23. N Engl J Med. 1998 Jul 30;339(5):321-8 - PubMed
  24. Cerebrovasc Dis. 2012;34(3):240-5 - PubMed
  25. Stroke. 2015 Mar;46(3):659-66 - PubMed
  26. Histochem J. 2001 Feb;33(2):87-90 - PubMed
  27. Curr Neurovasc Res. 2007 Aug;4(3):170-5 - PubMed
  28. Neurology. 1999 Jul 13;53(1):126-31 - PubMed
  29. Stroke. 2001 Nov;32(11):2559-66 - PubMed

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