Display options
Cite
Yamamoto K, Doki N, Senoo Y, et al. Severe Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic Stem Cell Transplantation after Only the First Administration of Granulocyte-Colony Stimulating Factor. Transfus Med Hemother. 2016;43(6):433-435doi: 10.1159/000446814.
Yamamoto, K., Doki, N., Senoo, Y., Najima, Y., Kobayashi, T., Kakihana, K., Haraguchi, K., Okuyama, Y., Sakamaki, H., & Ohashi, K. (2016). Severe Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic Stem Cell Transplantation after Only the First Administration of Granulocyte-Colony Stimulating Factor. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 43(6), 433-435. https://doi.org/10.1159/000446814
Yamamoto, Keita, et al. "Severe Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic Stem Cell Transplantation after Only the First Administration of Granulocyte-Colony Stimulating Factor." Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie vol. 43,6 (2016): 433-435. doi: https://doi.org/10.1159/000446814
Yamamoto K, Doki N, Senoo Y, Najima Y, Kobayashi T, Kakihana K, Haraguchi K, Okuyama Y, Sakamaki H, Ohashi K. Severe Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic Stem Cell Transplantation after Only the First Administration of Granulocyte-Colony Stimulating Factor. Transfus Med Hemother. 2016 Nov;43(6):433-435. doi: 10.1159/000446814. Epub 2016 Oct 18. PMID: 27994532; PMCID: PMC5159728.
Copy Download .nbib Format: NLM
Share it on

Transfus Med Hemother. 2016 Nov;43(6):433-435. doi: 10.1159/000446814. Epub 2016 Oct 18.

Severe Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic Stem Cell Transplantation after Only the First Administration of Granulocyte-Colony Stimulating Factor.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Keita Yamamoto, Noriko Doki, Yasushi Senoo, Yuho Najima, Takeshi Kobayashi, Kazuhiko Kakihana, Kyoko Haraguchi, Yoshiki Okuyama, Hisashi Sakamaki, Kazuteru Ohashi

Affiliations

  1. Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
  2. Division of Transfusion and Cell Therapy, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.

PMID: 27994532 PMCID: PMC5159728 DOI: 10.1159/000446814

Abstract

BACKGROUND: Granulocyte-colony stimulating factor (G-CSF) is widely used to mobilize peripheral blood stem cells (PBSCs) in healthy donors. A few reports have shown that some healthy donors developed acute respiratory distress syndrome or capillary leak syndrome after more than several rounds of G-CSF administration or leukapheresis.

CASE REPORT: We report the case of a healthy donor for allogeneic stem cell transplantation who developed severe hypoxemia 1 h after only the first administration of G-CSF. The donor was administered 10 μg/kg G-CSF (lenograstim) subcutaneously for PBSC mobilization. 1 h after the first administration of G-CSF, the donor suddenly presented with dry cough and dyspnea. The oxygen saturation by pulse oximetry (SpO

CONCLUSION: These respiratory symptoms might be related to anaphylactoid or hypersensitivity reaction. The donors should be observed for at least 1 h after the first administration of G-CSF.

Keywords: Allo-HSCT; Allogeneic hematopoietic stem cell transplantation; G-CSF; Granulocyte-colony stimulating factor; Healthy donor; PBSCs; Peripheral blood stem cells; Severe hypoxemia

References

  1. Transfus Med Hemother. 2013 Aug;40(4):225-35 - PubMed
  2. Transfusion. 2006 Feb;46(2):186-92 - PubMed
  3. Chest. 2001 Nov;120(5):1695-701 - PubMed
  4. Thorax. 2003 Oct;58(10 ):872-5 - PubMed
  5. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):818-24 - PubMed
  6. Haematologica. 2005 Mar;90(3):ECR10 - PubMed
  7. Blood. 2013 Jan 3;121(1):197-206 - PubMed
  8. Chest. 2002 May;121(5):1716-20 - PubMed
  9. N Engl J Med. 1991 Aug 22;325(8):587 - PubMed
  10. Bone Marrow Transplant. 2009 Jul;44(2):129-30 - PubMed
  11. Bone Marrow Transplant. 2001 Aug;28(3):311-2 - PubMed
  12. Eur J Cancer. 1995 Dec;31A(13-14):2428 - PubMed
  13. Transfus Med Rev. 2008 Oct;22(4):280-90 - PubMed
  14. Bone Marrow Transplant. 1999 Jan;23(2):200-1 - PubMed
  15. Transfus Med. 2013 Feb;23(1):69-71 - PubMed
  16. Transfusion. 2013 May;53(5):1146-7 - PubMed

Publication Types