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Alasvand M, Javanmard SH, Rashidi B, et al. Myocardial capillary density after neuropeptide Y antagonist administration in normal and high-fat diet C57BL6 mice. Adv Biomed Res. 2016;5:165doi: 10.4103/2277-9175.190998.
Alasvand, M., Javanmard, S. H., Rashidi, B., & Khazaei, M. (2016). Myocardial capillary density after neuropeptide Y antagonist administration in normal and high-fat diet C57BL6 mice. Advanced biomedical research, 5165. https://doi.org/10.4103/2277-9175.190998
Alasvand, Masoud, et al. "Myocardial capillary density after neuropeptide Y antagonist administration in normal and high-fat diet C57BL6 mice." Advanced biomedical research vol. 5 (2016): 165. doi: https://doi.org/10.4103/2277-9175.190998
Alasvand M, Javanmard SH, Rashidi B, Khazaei M. Myocardial capillary density after neuropeptide Y antagonist administration in normal and high-fat diet C57BL6 mice. Adv Biomed Res. 2016 Oct 26;5:165. doi: 10.4103/2277-9175.190998. eCollection 2016. PMID: 27995104; PMCID: PMC5137228.
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Adv Biomed Res. 2016 Oct 26;5:165. doi: 10.4103/2277-9175.190998. eCollection 2016.

Myocardial capillary density after neuropeptide Y antagonist administration in normal and high-fat diet C57BL6 mice.

Advanced biomedical research

Masoud Alasvand, Shaghayegh Haghjooy Javanmard, Bahman Rashidi, Majid Khazaei

Affiliations

  1. Department of Physiology, Sanandaj University of Medical Sciences, Sanandaj, Iran.
  2. Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  3. Department of Anatomy, Isfahan University of Medical Sciences, Isfahan, Iran.
  4. Neurogenic Inflammatory Research Center and Department of Physiology, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 27995104 PMCID: PMC5137228 DOI: 10.4103/2277-9175.190998

Abstract

BACKGROUND: Neuropeptide Y (NPY), a 36 amino acid peptide, has several effects on cardiovascular system. It is demonstrated that the angiogenic activity of NPY is similar to fibroblast growth factor and vascular endothelial growth factor (VEGF). The aim of this study was to evaluate the effect of systemic administration of antagonist of NPY receptor (BIIE0742) on coronary angiogenesis in normal and diet-induced obese animals.

MATERIALS AND METHODS: Twenty-four male mice were received high-fat diet (HFD) or normal diet (ND) for 14 weeks. Then, each group was randomized to the treatment of antagonist of NPY receptor (BIIE0246) or saline as following: ND+ BIIE0246 (100 μl/kg; i.p.), ND+ saline, HFD+ BIIE0246, HFD+ saline. After 14 days, blood samples were taken, and myocardial tissue (left ventricle) from all experimental groups was evaluated by immunohistochemistry.

RESULTS: Serum VEGF concentration and VEGF: Soluble VEGF receptor (sVEGFR)-1 ratio in obese animals was higher than normal group. Administration of BIIE0246 significantly reduced serum VEGF and VEGF: sVEGFR-1 ratio and increased serum sVEGFR-1 concentrations in obese animals (

CONCLUSION: Administration of NPY antagonist impairs myocardial capillary density, reduces angiogenic factors and elevates anti-angiogenic factors, and there are no differences between obese and normal animals.

Keywords: Angiogenesis; coronary; neuropeptide Y

Conflict of interest statement

There are no conflicts of interest.

References

  1. Coron Artery Dis. 2014 Jan;25(1):73-8 - PubMed
  2. Iran J Basic Med Sci. 2012 Nov;15(6):1110-26 - PubMed
  3. J Mol Cell Cardiol. 2010 Dec;49(6):1022-30 - PubMed
  4. Basic Res Cardiol. 2011 Nov;106(6):897-909 - PubMed
  5. Iran J Basic Med Sci. 2015 May;18(5):443-8 - PubMed
  6. Clinics (Sao Paulo). 2011;66(8):1419-24 - PubMed
  7. Glob J Health Sci. 2015 Mar 26;7(7 Spec No):69-78 - PubMed
  8. Am J Physiol. 1997 Nov;273(5 Pt 2):H2091-104 - PubMed
  9. J Clin Invest. 2003 Jun;111(12):1853-62 - PubMed
  10. FASEB J. 2006 Sep;20(11):1924-6 - PubMed
  11. Nature. 1997 Apr 17;386(6626):671-4 - PubMed
  12. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1618-28 - PubMed
  13. J Mol Cell Cardiol. 2012 Dec;53(6):891-8 - PubMed
  14. Trends Cardiovasc Med. 2003 Feb;13(2):86-92 - PubMed
  15. J Biol Chem. 2006 Aug 18;281(33):23436-44 - PubMed
  16. Int J Cancer. 2012 Feb 1;130(3):497-508 - PubMed
  17. J Cell Mol Med. 2010 Mar;14(3):528-52 - PubMed
  18. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8938-43 - PubMed
  19. Pancreas. 2008 Aug;37(2):145-50 - PubMed
  20. Cell. 2002 Jun 14;109(6):693-705 - PubMed
  21. Peptides. 2003 Jan;24(1):99-106 - PubMed
  22. Pharmacol Ther. 2011 Jul;131(1):91-113 - PubMed

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