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Abbasivash R, Sane S, Golmohammadi M, et al. Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery. Adv Biomed Res. 2016;5:167doi: 10.4103/2277-9175.190943.
Abbasivash, R., Sane, S., Golmohammadi, M., Shokuhi, S., & Toosi, F. D. (2016). Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery. Advanced biomedical research, 5167. https://doi.org/10.4103/2277-9175.190943
Abbasivash, Rahman, et al. "Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery." Advanced biomedical research vol. 5 (2016): 167. doi: https://doi.org/10.4103/2277-9175.190943
Abbasivash R, Sane S, Golmohammadi M, Shokuhi S, Toosi FD. Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery. Adv Biomed Res. 2016 Oct 26;5:167. doi: 10.4103/2277-9175.190943. eCollection 2016. PMID: 27995106; PMCID: PMC5137231.
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Adv Biomed Res. 2016 Oct 26;5:167. doi: 10.4103/2277-9175.190943. eCollection 2016.

Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery.

Advanced biomedical research

Rahman Abbasivash, Shahryar Sane, Mitra Golmohammadi, Shahram Shokuhi, Fereshteh Danaye Toosi

Affiliations

  1. Department of Anesthesiology, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.

PMID: 27995106 PMCID: PMC5137231 DOI: 10.4103/2277-9175.190943

Abstract

BACKGROUND: Spinal anesthesia is an accepted technique in hip fracture surgery and prevention of this complication by sympathomimetic agents is of potential clinical significance. The aim of this study is to compare the effect of prophylactic phenylephrine versus ephedrine in the prevention of hypotension during spinal anesthesia in hip fracture surgery.

MATERIALS AND METHODS: Ninety-two patients undergoing hip fracture surgery with the American Society of Anesthesiologists I and II were randomized to receive prophylaxis with ephedrine or phenylephrine immediately before the spinal anesthesia. Patients in the ephedrine group received an intravenous (IV) bolus of 10 mg ephedrine, and patients in the phenylephrine group received an IV bolus of 50 μg phenylephrine. We recorded mean arterial pressure (MAP), systolic and diastolic blood pressure, heart rate every 3 min in the first 10 min and then every 5 min until 30 min after spinal anesthesia, nausea and vomiting, additional vasopressor, and atropine administration.

RESULTS: The frequency of hypotension was significantly lower in MAP, systolic and diastolic pressure in group phenylephrine in 3, 6, and 9 min after spinal anesthesia (

CONCLUSION: At the doses of ephedrine and phenylephrine administered in this trial, phenylephrine was better to prevent hypotension during hip fracture surgery with spinal anesthesia. Higher frequency of hypotension was observed in the ephedrine group.

Keywords: Ephedrine; hip fracture; hypotension; phenylephrine; spinal anesthesia

Conflict of interest statement

There are no conflicts of interest.

References

  1. N Engl J Med. 1996 Jun 6;334(23):1519-25 - PubMed
  2. Anesthesiology. 2000 Jul;93(1):115-21 - PubMed
  3. BMC Anesthesiol. 2014 Oct 24;14:97 - PubMed
  4. J Trauma. 1985 Apr;25(4):309-16 - PubMed
  5. Neuroscience. 1994 Apr;59(3):589-98 - PubMed
  6. Can J Anaesth. 1998 Apr;45(4):367-9 - PubMed
  7. Rev Esp Anestesiol Reanim. 2011 Aug-Sep;58(7):412-6 - PubMed
  8. Anesth Analg. 2002 Sep;95(3):751-6, table of contents - PubMed
  9. Rev Bras Anestesiol. 2009 Jan-Feb;59(1):11-20 - PubMed
  10. Br J Anaesth. 1986 Mar;58(3):284-91 - PubMed
  11. Anesth Analg. 1997 Jul;85(1):99-105 - PubMed
  12. Clin Orthop Relat Res. 1984 Jun;(186):45-56 - PubMed
  13. Rev Bras Anestesiol. 2014 Sep-Oct;64(5):299-306 - PubMed
  14. Acta Anaesthesiol Scand Suppl. 1988;89:44-8 - PubMed
  15. Br J Anaesth. 1987 Sep;59(9):1080-8 - PubMed

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