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Yıldız ÖK, Balaban H, Özdemir S, et al. Anti-GQ1b-Negative Miller Fisher Syndrome with Acute Areflexic Mydriasis and Cholinergic Supersensitivity. Neuroophthalmology. 2011;35(1):40-42doi: 10.3109/01658107.2010.539761.
Yıldız, �. �. K., Balaban, H., Özdemir, S., Bolayır, E., & Topaktas, S. (2011). Anti-GQ1b-Negative Miller Fisher Syndrome with Acute Areflexic Mydriasis and Cholinergic Supersensitivity. Neuro-ophthalmology (Aeolus Press), 35(1), 40-42. https://doi.org/10.3109/01658107.2010.539761
Yıldız, Özlem Kayım, et al. "Anti-GQ1b-Negative Miller Fisher Syndrome with Acute Areflexic Mydriasis and Cholinergic Supersensitivity." Neuro-ophthalmology (Aeolus Press) vol. 35,1 (2011): 40-42. doi: https://doi.org/10.3109/01658107.2010.539761
Yıldız ÖK, Balaban H, Özdemir S, Bolayır E, Topaktas S. Anti-GQ1b-Negative Miller Fisher Syndrome with Acute Areflexic Mydriasis and Cholinergic Supersensitivity. Neuroophthalmology. 2011 Jan 16;35(1):40-42. doi: 10.3109/01658107.2010.539761. eCollection 2011. PMID: 27956933; PMCID: PMC5145285.
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Neuroophthalmology. 2011 Jan 16;35(1):40-42. doi: 10.3109/01658107.2010.539761. eCollection 2011.

Anti-GQ1b-Negative Miller Fisher Syndrome with Acute Areflexic Mydriasis and Cholinergic Supersensitivity.

Neuro-ophthalmology (Aeolus Press)

Özlem Kayım Yıldız, Hatice Balaban, Sibel Özdemir, Ertuğrul Bolayır, Suat Topaktas

Affiliations

  1. Department of Neurology, Cumhuriyet University School of Medicine, Sivas, Turkey.

PMID: 27956933 PMCID: PMC5145285 DOI: 10.3109/01658107.2010.539761

Abstract

Miller Fisher syndrome is a rare variant of Guillain-Barré syndrome and it is characterised by ophthalmoplegia, ataxia, and areflexia. Pupillomotor involvement occurs in approximately half of the patients with the disorder. The authors report a patient with acute areflexic mydriasis, external ophthalmoplegia, areflexia, and ataxia. Although the pupils were unreactive to light and near stimuli, administration of 0.1% pilocarpine resulted in marked miosis, suggesting cholinergic supersensitivity. Antibodies against GM1, GD1b, and GQ1b were negative. This is the first report of acute areflexic mydriasis with cholinergic supersensitivity in anti-GQ1b-negative Miller Fisher syndrome.

Keywords: Miller Fisher syndrome; anti-GQ1b; cholinergic supersensitivity; mydriasis

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