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Souza-Silva BN, Rodrigues JA, Moreira JC, et al. The influence of teriparatide in induced tooth movement: A systematic review. J Clin Exp Dent. 2016;8(5):e615-e621doi: 10.4317/jced.52997.
Souza-Silva, B. N., Rodrigues, J. A., Moreira, J. C., Matos, F. S., Cesar, C. P., Repeke, C. E., & Paranhos, L. R. (2016). The influence of teriparatide in induced tooth movement: A systematic review. Journal of clinical and experimental dentistry, 8(5), e615-e621. https://doi.org/10.4317/jced.52997
Souza-Silva, Bianca-Núbia, et al. "The influence of teriparatide in induced tooth movement: A systematic review." Journal of clinical and experimental dentistry vol. 8,5 (2016): e615-e621. doi: https://doi.org/10.4317/jced.52997
Souza-Silva BN, Rodrigues JA, Moreira JC, Matos FS, Cesar CP, Repeke CE, Paranhos LR. The influence of teriparatide in induced tooth movement: A systematic review. J Clin Exp Dent. 2016 Dec 01;8(5):e615-e621. doi: 10.4317/jced.52997. eCollection 2016 Dec. PMID: 27957280; PMCID: PMC5149101.
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J Clin Exp Dent. 2016 Dec 01;8(5):e615-e621. doi: 10.4317/jced.52997. eCollection 2016 Dec.

The influence of teriparatide in induced tooth movement: A systematic review.

Journal of clinical and experimental dentistry

Bianca-Núbia Souza-Silva, José-Lucas-Sani-de Alcântara Rodrigues, Jefferson-Chaves Moreira, Felipe-de Souza Matos, Carla-Patrícia-Hernandez-Alves-Ribeiro Cesar, Carlos-Eduardo-Palanch Repeke, Luiz-Renato Paranhos

Affiliations

  1. Undergraduate student, Department of Dentistry, Federal University of Sergipe, Lagarto, SE, Brazil.
  2. DDS, MSc, Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, SE, Brazil.
  3. DDS, MSc, PhD, Professor, Department of Speech Therapy, Federal University of Sergipe, Lagarto, SE, Brazil.
  4. DDS, MSc, PhD, Professor, Department of Dentistry, Federal University of Sergipe, Lagarto, SE, Brazil.

PMID: 27957280 PMCID: PMC5149101 DOI: 10.4317/jced.52997

Abstract

BACKGROUND: Teriparatide is a synthetic drug similar than PTH (parathyroid hormone), which is currently used as long-term treatment option for patients with bone chronic diseases, as osteoporosis; and this drug can interfere in a positive way in orthodontic movement. Objectives: The medical literature was assessed in the present systematic review in order to determine the level of scientific evidence supporting the influence of teriparatide in induced tooth movement.

MATERIAL AND METHODS: The PRISMA Checklist was followed in this systematic review. Four electronic databases (PubMed; Scopus; ScienceDirect; OpenGrey) were searched without implementing restrictions of year, status, and language of publications. The inclusion criteria consisted of selecting only experimental studies comparing the influence of teriparatide in tooth movement of male Wistar rats. The exclusion criteria consisted of experiments with female rats or other experimental animals, and animals with pathologic conditions. The eligible studies were evaluated based on methodological quality. Two trained examiners performed all the research steps.

RESULTS: The initial sample comprised 700 studies, which was reduced to 664 after the exclusion of duplicates (n=36). Three articles were selected for the final qualitative analysis. The local administration of parathyroid hormone (PTH) 1-34 or PTH 1-84 revealed major effectiveness when compared with control groups and systematic administration. Additionally, the dilution of PTH 1-34 within methyl cellulose (MC) gel increased the time range for drug release, enabling to reduce the drug concentration without decreasing the effectiveness of tooth movement.

CONCLUSIONS: Teriparatide demonstrated potential acceleration of tooth movement in Wistar rats depending on the drug concentration; drug administration; and time for drug release.

Conflict of interest statement

The authors declare that they have no conflict of interest in this study.

References

  1. Eur J Oral Sci. 2007 Oct;115(5):355-62 - PubMed
  2. Am J Orthod Dentofacial Orthop. 2013 Oct;144(4):523-32 - PubMed
  3. Nat Rev Endocrinol. 2011 Jul 12;7(11):647-56 - PubMed
  4. Case Rep Endocrinol. 2014;2014:802473 - PubMed
  5. Gerontology. 2016;62(2):128-37 - PubMed
  6. Cytokine. 2008 Jun;42(3):330-5 - PubMed
  7. J Bone Miner Res. 1999 Apr;14 (4):546-54 - PubMed
  8. Gene. 2002 Jan 9;282(1-2):1-17 - PubMed
  9. PLoS Med. 2009 Jul 21;6(7):e1000100 - PubMed
  10. J Clin Endocrinol Metab. 1998 Aug;83(8):2786-91 - PubMed
  11. Nat Rev Endocrinol. 2015 May;11(5):298-307 - PubMed
  12. Dentomaxillofac Radiol. 2015;44(4):20140270 - PubMed
  13. Pharm Res. 1995 Dec;12(12):1997-2002 - PubMed
  14. Nat Rev Rheumatol. 2012 Nov;8(11):684-9 - PubMed
  15. Orthod Craniofac Res. 2009 May;12 (2):113-9 - PubMed
  16. Expert Opin Pharmacother. 2004 May;5(5):1153-62 - PubMed
  17. J Clin Immunol. 2009 Sep;29(5):555-67 - PubMed
  18. Eur J Oral Sci. 2011 Feb;119(1):7-14 - PubMed
  19. J Dent Res. 2000 Sep;79(9):1717-24 - PubMed
  20. Oral Dis. 2015 Sep;21(6):694-704 - PubMed

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