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Shahbazian N, Jafari RM, Haghnia S. The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia. Electron Physician. 2016;8(10):3057-3061doi: 10.19082/3057.
Shahbazian, N., Jafari, R. M., & Haghnia, S. (2016). The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia. Electronic physician, 8(10), 3057-3061. https://doi.org/10.19082/3057
Shahbazian, Nahid, et al. "The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia." Electronic physician vol. 8,10 (2016): 3057-3061. doi: https://doi.org/10.19082/3057
Shahbazian N, Jafari RM, Haghnia S. The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia. Electron Physician. 2016 Oct 25;8(10):3057-3061. doi: 10.19082/3057. eCollection 2016 Oct. PMID: 27957303; PMCID: PMC5133028.
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Electron Physician. 2016 Oct 25;8(10):3057-3061. doi: 10.19082/3057. eCollection 2016 Oct.

The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia.

Electronic physician

Nahid Shahbazian, Razieh Mohammad Jafari, Sahar Haghnia

Affiliations

  1. M.D., Gynecologist, Full Professor, Department of Obstetrics and Gynecology, Fertility, Infertility and Perinatology Research Center, Faculty of Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.
  2. M.D., Gynecologist, Associate Professor, Department of Obstetrics and Gynecology, Fertility, Infertility and Perinatology Research Center, Faculty of Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.
  3. M.D., Resident of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Fertility, Infertility and Perinatology Research Center, Faculty of Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.

PMID: 27957303 PMCID: PMC5133028 DOI: 10.19082/3057

Abstract

INTRODUCTION: Increased plasma homocysteine may be associated with adverse pregnancy outcomes, such as preeclampsia. The aim of this study was to determine the plasma homocysteine, serum folate, and vitamin B12 levels in preeclamptic pregnant women.

METHODS: This case-control study was conducted in 2016 in Ahwaz on 51 pregnant women with preeclampsia and 51 healthy pregnant women of the same gestational age, who served as controls. The case group also was subdivided into severe and non-severe preeclampsia. Patients' data were collected through a questionnaire and medical records. Serum homocysteine, folic acid, and vitamin B12 were analyzed using chemiluminescent assay. The results were compared between two groups. Statistical analyses were done using IBM-SPSS 20.0. A Kolmogorov-Smirnov test, independent samples t-test, Mann-Whitney test, and Chi-square test were used for data analysis.

RESULTS: No different demographic characteristics were found among the groups. Pregnant women complicated with preeclampsia displayed significantly higher serum homocysteine levels (p < 0.001) and lower serum folate (p = 0.005) and vitamin B12 levels (p < 0.001) compared to controls. A statistically significant inverse correlation was evident between serum homocysteine and serum folate levels in preeclamptic patients (p = 0.005; r = -0.389). In addition, an inverse correlation was identified between homocysteine and serum vitamin B12, but it was not statistically significant (p = 0.160; r = -0.200). Significant differences occurred in serum homocysteine and folate levels between the severe and non-severe subgroups (p < 0.001, p < 0.001).

CONCLUSION: Women complicated with preeclampsia displayed higher maternal serum homocysteine and lower serum folate and vitamin B12. Further studies are needed to confirm if the prescription of folic acid and vitamin B12 in women with a deficiency of these vitamins could decrease the level of serum homocysteine and, therefore, reduce the risk of preeclampsia or, if it occurred, its severity.

Keywords: Folic acid; Homocysteine; Preeclampsia; Vitamin B12

Conflict of interest statement

There is no conflict of interest to be declared.

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