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Del Turco D, Paul MH, Schlaudraff J, et al. Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus. Front Mol Neurosci. 2016;9:134doi: 10.3389/fnmol.2016.00134.
Del Turco, D., Paul, M. H., Schlaudraff, J., Hick, M., Endres, K., Müller, U. C., & Deller, T. (2016). Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus. Frontiers in molecular neuroscience, 9134. https://doi.org/10.3389/fnmol.2016.00134
Del Turco, Domenico, et al. "Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus." Frontiers in molecular neuroscience vol. 9 (2016): 134. doi: https://doi.org/10.3389/fnmol.2016.00134
Del Turco D, Paul MH, Schlaudraff J, Hick M, Endres K, Müller UC, Deller T. Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus. Front Mol Neurosci. 2016 Nov 29;9:134. doi: 10.3389/fnmol.2016.00134. eCollection 2016. PMID: 27965537; PMCID: PMC5126089.
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Front Mol Neurosci. 2016 Nov 29;9:134. doi: 10.3389/fnmol.2016.00134. eCollection 2016.

Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus.

Frontiers in molecular neuroscience

Domenico Del Turco, Mandy H Paul, Jessica Schlaudraff, Meike Hick, Kristina Endres, Ulrike C Müller, Thomas Deller

Affiliations

  1. Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University Frankfurt, Germany.
  2. Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe-UniversityFrankfurt, Germany; Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg UniversityHeidelberg, Germany.
  3. Clinic for Psychiatry and Psychotherapy, University Medical Center Mainz Mainz, Germany.
  4. Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University Heidelberg, Germany.

PMID: 27965537 PMCID: PMC5126089 DOI: 10.3389/fnmol.2016.00134

Abstract

The physiological role of amyloid precursor protein (APP) has been extensively investigated in the rodent hippocampus. Evidence suggests that APP plays a role in synaptic plasticity, dendritic and spine morphogenesis, neuroprotection and-at the behavioral level-hippocampus-dependent forms of learning and memory. Intriguingly, however, studies focusing on the role of APP in synaptic plasticity have reported diverging results and considerable differences in effect size between the dentate gyrus (DG) and area CA1 of the mouse hippocampus. We speculated that regional differences in APP expression could underlie these discrepancies and studied the expression of APP in both regions using immunostaining,

Keywords: APP; CA1; RT-qPCR; dentate gyrus; immunostaining; in situ hybridization; laser microdissection; western blotting

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