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Chang S, Holmes M, Mowat J, et al. α-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones. Angew Chem Int Ed Engl. 2016;56(3):748-752doi: 10.1002/anie.201608449.
Chang, S., Holmes, M., Mowat, J., Meanwell, M., & Britton, R. (2017). α-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones. Angewandte Chemie (International ed. in English), 56(3), 748-752. https://doi.org/10.1002/anie.201608449
Chang, Stanley, et al. "α-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones." Angewandte Chemie (International ed. in English) vol. 56,3 (2017): 748-752. doi: https://doi.org/10.1002/anie.201608449
Chang S, Holmes M, Mowat J, Meanwell M, Britton R. α-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones. Angew Chem Int Ed Engl. 2017 Jan 16;56(3):748-752. doi: 10.1002/anie.201608449. Epub 2016 Dec 15. PMID: 27976511.
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Angew Chem Int Ed Engl. 2017 Jan 16;56(3):748-752. doi: 10.1002/anie.201608449. Epub 2016 Dec 15.

α-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones.

Angewandte Chemie (International ed. in English)

Stanley Chang, Michael Holmes, Jeffrey Mowat, Michael Meanwell, Robert Britton

Affiliations

  1. Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.

PMID: 27976511 DOI: 10.1002/anie.201608449

Abstract

α-Arylcyclobutanones display unique reactivity that makes them valuable synthetic intermediates and target molecules. We describe the preparation of α-aryl- and α-heteroarylcyclobutanones through a direct α-arylation reaction. Problematic fragmentations are avoided by the use of LiO

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: cyclobutanones; homogeneous catalysis; ring expansion; synthetic methods; α-arylation

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