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Thijs JL, Knipping K, Bruijnzeel-Koomen CA, et al. Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity. Clin Transl Allergy. 2016;6:44doi: 10.1186/s13601-016-0132-9.
Thijs, J. L., Knipping, K., Bruijnzeel-Koomen, C. A., Garssen, J., de Bruin-Weller, M. S., & Hijnen, D. J. (2016). Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity. Clinical and translational allergy, 644. https://doi.org/10.1186/s13601-016-0132-9
Thijs, J L, et al. "Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity." Clinical and translational allergy vol. 6 (2016): 44. doi: https://doi.org/10.1186/s13601-016-0132-9
Thijs JL, Knipping K, Bruijnzeel-Koomen CA, Garssen J, de Bruin-Weller MS, Hijnen DJ. Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity. Clin Transl Allergy. 2016 Dec 06;6:44. doi: 10.1186/s13601-016-0132-9. eCollection 2016. PMID: 27980722; PMCID: PMC5139123.
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Clin Transl Allergy. 2016 Dec 06;6:44. doi: 10.1186/s13601-016-0132-9. eCollection 2016.

Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity.

Clinical and translational allergy

J L Thijs, K Knipping, C A F Bruijnzeel-Koomen, J Garssen, M S de Bruin-Weller, D J Hijnen

Affiliations

  1. Department of Dermatology and Allergology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
  2. Nutricia Research, Utrecht, The Netherlands ; Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

PMID: 27980722 PMCID: PMC5139123 DOI: 10.1186/s13601-016-0132-9

Abstract

BACKGROUND: Although total IgE levels have been proposed as a biomarker for disease severity in atopic dermatitis (AD) and are increased in the majority of AD patients, they do not correlate with disease severity during short-term follow-up. During the synthesis of immunoglobulins, free light chains (Ig-FLCs) are produced in excess over heavy chains. In comparison with IgE molecules, Ig-FLCs have a very short serum half-life. Therefore, Ig-FLCs might be more suitable as a biomarker for disease severity during follow-up. Recent studies showed increased serum levels of kappa Ig-FLCs in infants with AD, correlating with disease severity. The aim of this study was to investigate serum kappa Ig-FLC levels in adults with AD, and their correlation to disease severity.

METHODS: Serum kappa If-FLC and total IgE levels were measured in 82 moderate to severe AD patients and 49 non-atopic controls. Blood was collected from patients before start of treatment with potent topical steroids (European classification: III-IV). 32 patients were treated during a clinical admission, and in this subpopulation a second blood sample was taken after 2 weeks of treatment. Clinical severity was determined by the Six Area Six Sign Atopic Dermatitis (SASSAD) severity score and a panel of serum biomarkers, including thymus and activation-regulated chemokine (TARC).

RESULTS: Serum kappa Ig-FLCs levels in adult AD patients were not increased compared to non-atopic controls. Moreover, we observed no correlation between kappa Ig-FLC serum levels and disease severity determined by SASSAD and a panel of serum biomarkers, including TARC. Serum kappa Ig-FLC levels did also not decrease during treatment.

CONCLUSION: There are no differences in serum kappa Ig-FLC levels between adult patients suffering from moderate to severe AD compared to non-atopic controls. Moreover, serum levels of kappa Ig-FLCs cannot be used as a biomarker for disease severity in adult AD.

Keywords: Atopic dermatitis; Biomarker; Eczema; Free light chains; Serum kappa Ig-FLCs; Total IgE

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