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Wei S, Ma Y, Luo J, et al. Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology. Carbohydr Polym. 2016;157:953-961doi: 10.1016/j.carbpol.2016.10.043.
Wei, S., Ma, Y., Luo, J., He, X., Yue, P., Guan, Z., & Yang, M. (2017). Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology. Carbohydrate polymers, 157953-961. https://doi.org/10.1016/j.carbpol.2016.10.043
Wei, Shaofeng, et al. "Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology." Carbohydrate polymers vol. 157 (2017): 953-961. doi: https://doi.org/10.1016/j.carbpol.2016.10.043
Wei S, Ma Y, Luo J, He X, Yue P, Guan Z, Yang M. Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology. Carbohydr Polym. 2017 Feb 10;157:953-961. doi: 10.1016/j.carbpol.2016.10.043. Epub 2016 Oct 17. PMID: 27988014.
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Carbohydr Polym. 2017 Feb 10;157:953-961. doi: 10.1016/j.carbpol.2016.10.043. Epub 2016 Oct 17.

Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology.

Carbohydrate polymers

Shaofeng Wei, Yueqin Ma, Jing Luo, Xiaoru He, Pengfei Yue, Zhiyu Guan, Ming Yang

Affiliations

  1. Jiangxi University of Traditional Chinese Medicine, 818 MEILINGDADAO Road, Nanchang 330004, China.
  2. Department of Pharmaceutics, 94th Hospital of People's Liberation Army, Nanchang 330000, China.
  3. Jiangxi University of Traditional Chinese Medicine, 818 MEILINGDADAO Road, Nanchang 330004, China. Electronic address: [email protected].

PMID: 27988014 DOI: 10.1016/j.carbpol.2016.10.043

Abstract

The objective of this study is to design novel dissolution-enhanced microparticles loaded poorly soluble drug nanocrystals used a low viscosity of hydroxypropylcellulose (HPC) as matrix carrier. An interesting approach combined homogenization and the spray-freeze-drying technique was developed. The results demonstrated that the ratio of HPC to drug played an important role in size-reduction efficiency of drug during homogenization. And the formation of cage-like structure of the composite particles depended on ratio of HPC to drug. The spray-freeze-dried composite particles with HPC ratio of 1:2, 1:1 and 2:1 possessed excellent redispersibility, which attributed to its porous matrix and large surface area (3000m

Copyright © 2016 Elsevier Ltd. All rights reserved.

Keywords: Cage-like microparticles; Hydroxypropylcellulose; Nanocrystals; Redispersibility; Spray-freeze-drying

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