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Yao WC, Emerick KS, Kraft S, et al. Nasal mucosal melanosis may act as a harbinger of melanoma: A case report. Allergy Rhinol (Providence). 2016;7(3):164-167doi: 10.2500/ar.2016.7.0174.
Yao, W. C., Emerick, K. S., Kraft, S., & Holbrook, E. H. (2016). Nasal mucosal melanosis may act as a harbinger of melanoma: A case report. Allergy & rhinology (Providence, R.I.), 7(3), 164-167. https://doi.org/10.2500/ar.2016.7.0174
Yao, William C, et al. "Nasal mucosal melanosis may act as a harbinger of melanoma: A case report." Allergy & rhinology (Providence, R.I.) vol. 7,3 (2016): 164-167. doi: https://doi.org/10.2500/ar.2016.7.0174
Yao WC, Emerick KS, Kraft S, Holbrook EH. Nasal mucosal melanosis may act as a harbinger of melanoma: A case report. Allergy Rhinol (Providence). 2016 Jan 01;7(3):164-167. doi: 10.2500/ar.2016.7.0174. PMID: 28107150; PMCID: PMC5244274.
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Allergy Rhinol (Providence). 2016 Jan 01;7(3):164-167. doi: 10.2500/ar.2016.7.0174.

Nasal mucosal melanosis may act as a harbinger of melanoma: A case report.

Allergy & rhinology (Providence, R.I.)

William C Yao, Kevin S Emerick, Stefan Kraft, Eric H Holbrook

PMID: 28107150 PMCID: PMC5244274 DOI: 10.2500/ar.2016.7.0174

Abstract

BACKGROUND: The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time.

OBJECTIVE: To describe a transformation of a mucosal melanosis into melanoma.

METHODS: A 53-year-old man with diffuse melanosis of the nasal cavity underwent surgical resection.

RESULTS: Pathology revealed melanocytic hyperplasia without evidence of melanoma. The patient was serially examined, with excisions for new areas of melanosis. The pathology progressed to severely atypical melanocytic proliferation and melanoma in situ over a 4-year period.

CONCLUSION: Nasal melanosis may be a precancerous lesion and may transform into melanoma. All melanosis should be biopsied with close endoscopic observation. Lesions with dysplasia or atypia should be excised due to potential transformation to melanoma.

Conflict of interest statement

The authors have no conflicts of interest to declare pertaining to this article

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