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Shepherd S, Batra A, Lerner DP. Review of Critical Illness Myopathy and Neuropathy. Neurohospitalist. 2016;7(1):41-48doi: 10.1177/1941874416663279.
Shepherd, S., Batra, A., & Lerner, D. P. (2017). Review of Critical Illness Myopathy and Neuropathy. The Neurohospitalist, 7(1), 41-48. https://doi.org/10.1177/1941874416663279
Shepherd, Starane, et al. "Review of Critical Illness Myopathy and Neuropathy." The Neurohospitalist vol. 7,1 (2017): 41-48. doi: https://doi.org/10.1177/1941874416663279
Shepherd S, Batra A, Lerner DP. Review of Critical Illness Myopathy and Neuropathy. Neurohospitalist. 2017 Jan;7(1):41-48. doi: 10.1177/1941874416663279. Epub 2016 Aug 23. PMID: 28042370; PMCID: PMC5167093.
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Neurohospitalist. 2017 Jan;7(1):41-48. doi: 10.1177/1941874416663279. Epub 2016 Aug 23.

Review of Critical Illness Myopathy and Neuropathy.

The Neurohospitalist

Starane Shepherd, Ayush Batra, David P Lerner

Affiliations

  1. Department of Neurology, Brigham and Women's Hospital & Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

PMID: 28042370 PMCID: PMC5167093 DOI: 10.1177/1941874416663279

Abstract

Critical illness myopathy (CIM) and neuropathy are underdiagnosed conditions within the intensive care setting and contribute to prolonged mechanical ventilation and ventilator wean failure and ultimately lead to significant morbidity and mortality. These conditions are often further subdivided into CIM, critical illness polyneuropathy (CIP), or the combination-critical illness polyneuromyopathy (CIPNM). In this review, we discuss the epidemiology and pathophysiology of CIM, CIP, and CIPNM, along with diagnostic considerations such as detailed clinical examination, electrophysiological studies, and histopathological review of muscle biopsy specimens. We also review current available treatments and prognosis. Increased awareness and early recognition of CIM, CIP, and CIPNM in the intensive care unit setting may lead to earlier treatments and rehabilitation, improving patient outcomes.

Keywords: EMG/NCV; muscular disease; neurocritical care; neuromuscular disease; polyneuropathies

Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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