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Zhao N, Liu Y, Liang H, et al. Bone marrow-derived mesenchymal stem cells reduce immune reaction in a mouse model of allergic rhinitis. Am J Transl Res. 2016;8(12):5628-5636
Zhao, N., Liu, Y., Liang, H., & Jiang, X. (2016). Bone marrow-derived mesenchymal stem cells reduce immune reaction in a mouse model of allergic rhinitis. American journal of translational research, 8(12), 5628-5636.
Zhao, Ning, et al. "Bone marrow-derived mesenchymal stem cells reduce immune reaction in a mouse model of allergic rhinitis." American journal of translational research vol. 8,12 (2016): 5628-5636.
Zhao N, Liu Y, Liang H, Jiang X. Bone marrow-derived mesenchymal stem cells reduce immune reaction in a mouse model of allergic rhinitis. Am J Transl Res. 2016 Dec 15;8(12):5628-5636. eCollection 2016. PMID: 28078033; PMCID: PMC5209513.
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Am J Transl Res. 2016 Dec 15;8(12):5628-5636. eCollection 2016.

Bone marrow-derived mesenchymal stem cells reduce immune reaction in a mouse model of allergic rhinitis.

American journal of translational research

Ning Zhao, Yanjuan Liu, Hongfeng Liang, Xuejun Jiang

Affiliations

  1. Department of E. N. T., The First Hospital Affiliated of China Medical University 155 Nanjing Bei Street, Shenyang 110001, China.
  2. Department of E. N. T., The First Hospital Affiliated of Dalian Medical University 222 Zhongshan Road, Dalian 116013, China.

PMID: 28078033 PMCID: PMC5209513

Abstract

OBJECT: To determine the potential of bone marrow-derived mesenchymal stem cells (BMSCs) for immunomodulatory mechanism in mice model of allergic rhinitis (AR).

METHODS: BMSCs were isolated and the surface markers and stemness were analyzed. The effect of BMSCs was evaluated in BALB/c mice that were randomly divided into three groups (control group, ovalbumin (OVA) group, OVA+BMSCs group). BMSCs were administered intravenously to OVA sensitized mice on days 1, 7, 14 and 21, and subsequent OVA challenge was conducted daily from days 22 to 35. Several parameters of allergic inflammation were assessed.

RESULTS: Mesenchymal stem cells can be successfully isolated from bone marrow of mice. Intravenous injection of BMSCs significantly reduced allergic symptoms, eosinophil infiltration, OVA-specific immunoglobulin E (IgE), T-helper 2 (Th2) cytokine profile (interleukin (IL)-4, IL-5 and IL-13) and regulatory cytokines (IL-10). In addition, level of Th1 (IFN-γ) was significantly increased.

CONCLUSION: Administration of BMSCs effectively reduced allergic symptoms and inflammatory parameters in the mice model of AR. BMSCs treatment is potentially an alternative therapeutic modality in AR.

Keywords: Cell therapy; allergic rhinitis; cytokines; immunosuppression; mesenchymal stem cell

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