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Guo AC, Chu T, Liu XQ, et al. Reactivated astrocytes as a possible source of oligodendrocyte precursors for remyelination in remitting phase of experimental autoimmune encephalomyelitis rats. Am J Transl Res. 2016;8(12):5637-5645
Guo, A. C., Chu, T., Liu, X. Q., Su, H. X., & Wu, W. T. (2016). Reactivated astrocytes as a possible source of oligodendrocyte precursors for remyelination in remitting phase of experimental autoimmune encephalomyelitis rats. American journal of translational research, 8(12), 5637-5645.
Guo, An-Chen, et al. "Reactivated astrocytes as a possible source of oligodendrocyte precursors for remyelination in remitting phase of experimental autoimmune encephalomyelitis rats." American journal of translational research vol. 8,12 (2016): 5637-5645.
Guo AC, Chu T, Liu XQ, Su HX, Wu WT. Reactivated astrocytes as a possible source of oligodendrocyte precursors for remyelination in remitting phase of experimental autoimmune encephalomyelitis rats. Am J Transl Res. 2016 Dec 15;8(12):5637-5645. eCollection 2016. PMID: 28078034; PMCID: PMC5209514.
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Am J Transl Res. 2016 Dec 15;8(12):5637-5645. eCollection 2016.

Reactivated astrocytes as a possible source of oligodendrocyte precursors for remyelination in remitting phase of experimental autoimmune encephalomyelitis rats.

American journal of translational research

An-Chen Guo, Takho Chu, Xu-Qing Liu, Huan-Xing Su, Wu-Tian Wu

Affiliations

  1. Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong KongPokfulam, Hong Kong SAR, China; Laboratory of Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical UniversityBeijing, China; Key Laboratory of Translational Medicine for Cerebrovascular DiseaseBeijing, China.
  2. Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam, Hong Kong SAR, China.
  3. Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam, Hong Kong SAR, China.
  4. Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong KongPokfulam, Hong Kong SAR, China; State Key Laboratory for Brain and Cognitive Sciences, The University of Hong KongPokfulam, Hong Kong SAR, China; GHM Institute of CNS Regeneration, Jinan UniversityGuangzhou, China.

PMID: 28078034 PMCID: PMC5209514

Abstract

Multiple sclerosis (MS) is ademyelinating disease in the central nervous system (CNS). Majority of the MS patients show relapsing-remitting disease course. Evidences show that oligodendrocyte precursor cells (OPCs), which remain relatively quiescent in normal adult CNS, play a key role in the remitting phase by proliferation and remyelination. In the present study, we found that spinal cord astrocytesco-expressed progenitor cell marker and oligodendroglial lineage markers in the remittance phase in adult rat experimental autoimmune encephalomyelitis (EAE) model. We suggest that activated astrocyte could de-differentiate into OPCs and re-differentiate into mature oligodendrocytes, raising the possibility that astrocytes can be a potential source of OPCs in the adult demyelinated spinal cord.

Keywords: Oligodendrocyte; astrocytesco; encephalomyelitis; multiple sclerosis (MS)

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