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Int J Physiol Pathophysiol Pharmacol. 2016 Dec 25;8(4):146-151. eCollection 2016.

Amyloid beta peptide 22-35 induces a negative inotropic effect on isolated rat hearts.

International journal of physiology, pathophysiology and pharmacology

Neda Yousefirad, Ziya Kaygısız, Yasemin Aydın

Affiliations

  1. Department of Physiology, Faculty of Medicine, University of Eskisehir Osmangazi Eskisehir, Turkey.

PMID: 28078053 PMCID: PMC5209443

Abstract

Evidences indicate that deposition of amyloid beta peptides (Aβs) plays an important role in the pathogenesis of Alzheimer disease. Aβs may influence cardiovascular system and ileum contractions. But the effect of amyloid beta peptide 22-35 (Aβ

Keywords: Amyloid beta peptide 22-35; cardiac contractility; coronary flow; heart rate; ileum contraction; monophasic action potential

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