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Brandt N, Garvey LH, Bindslev-Jensen U, et al. Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid. Clin Transl Allergy. 2017;7:2doi: 10.1186/s13601-016-0138-3.
Brandt, N., Garvey, L. H., Bindslev-Jensen, U., Kjaer, H. F., Bindslev-Jensen, C., & Mortz, C. G. (2017). Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid. Clinical and translational allergy, 72. https://doi.org/10.1186/s13601-016-0138-3
Brandt, Nicolaj, et al. "Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid." Clinical and translational allergy vol. 7 (2017): 2. doi: https://doi.org/10.1186/s13601-016-0138-3
Brandt N, Garvey LH, Bindslev-Jensen U, Kjaer HF, Bindslev-Jensen C, Mortz CG. Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid. Clin Transl Allergy. 2017 Jan 10;7:2. doi: 10.1186/s13601-016-0138-3. eCollection 2017. PMID: 28078080; PMCID: PMC5223300.
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Clin Transl Allergy. 2017 Jan 10;7:2. doi: 10.1186/s13601-016-0138-3. eCollection 2017.

Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid.

Clinical and translational allergy

Nicolaj Brandt, Lene H Garvey, Ulla Bindslev-Jensen, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen, Charlotte G Mortz

Affiliations

  1. Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Sdr. Boulevard 29, 5000 Odense C, Denmark.
  2. Department of Dermatology and Allergy, Allergy Clinic, Gentofte Hospital, 2900 Hellerup, Denmark.

PMID: 28078080 PMCID: PMC5223300 DOI: 10.1186/s13601-016-0138-3

Abstract

We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredients including excipients.

Keywords: Anaphylaxis; Corticosteroids; Macrogols; Oral challenge; Skin testing

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