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Sethi T, Nguyen V, Li S, et al. Differences in outcome of patients with syncytial variant Hodgkin lymphoma compared with typical nodular sclerosis Hodgkin lymphoma. Ther Adv Hematol. 2016;8(1):13-20doi: 10.1177/2040620716676256.
Sethi, T., Nguyen, V., Li, S., Morgan, D., Greer, J., & Reddy, N. (2017). Differences in outcome of patients with syncytial variant Hodgkin lymphoma compared with typical nodular sclerosis Hodgkin lymphoma. Therapeutic advances in hematology, 8(1), 13-20. https://doi.org/10.1177/2040620716676256
Sethi, Tarsheen, et al. "Differences in outcome of patients with syncytial variant Hodgkin lymphoma compared with typical nodular sclerosis Hodgkin lymphoma." Therapeutic advances in hematology vol. 8,1 (2017): 13-20. doi: https://doi.org/10.1177/2040620716676256
Sethi T, Nguyen V, Li S, Morgan D, Greer J, Reddy N. Differences in outcome of patients with syncytial variant Hodgkin lymphoma compared with typical nodular sclerosis Hodgkin lymphoma. Ther Adv Hematol. 2017 Jan;8(1):13-20. doi: 10.1177/2040620716676256. Epub 2016 Oct 30. PMID: 28042455; PMCID: PMC5167078.
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Ther Adv Hematol. 2017 Jan;8(1):13-20. doi: 10.1177/2040620716676256. Epub 2016 Oct 30.

Differences in outcome of patients with syncytial variant Hodgkin lymphoma compared with typical nodular sclerosis Hodgkin lymphoma.

Therapeutic advances in hematology

Tarsheen Sethi, Van Nguyen, Shaoying Li, David Morgan, John Greer, Nishitha Reddy

Affiliations

  1. Vanderbilt University Medical Center, Nashville, TN, USA.
  2. University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  3. Vanderbilt University, 3927 The Vanderbilt Clinic, 1301 Medical Center Drive, Nashville, TN 37232, USA.

PMID: 28042455 PMCID: PMC5167078 DOI: 10.1177/2040620716676256

Abstract

BACKGROUND: Nodular sclerosis Hodgkin lymphoma (NS-HL) is the most common subtype of HL and usually has a good prognosis. A variant of NS, the syncytial variant (SV) has well-established histopathologic features but little is known about its clinical behavior. Small case series have suggested that SV patients present with advanced disease and have a comparatively aggressive course. The objective of this study was to determine the clinical characteristics and outcome of SV patients.

METHODS: A total of 167 adult patients with NS-HL including 43 patients with SV and 124 patients with typical NS (t-NS) were included in our analysis following institutional review board (IRB) approval. The Kaplan-Meier method was used to calculate the progression-free survival (PFS) and overall survival (OS). Log-rank test was used to determine the differences in survival.

RESULTS: Of the 167 patients, 43 were confirmed as SV based on morphology and immunophenotype. Doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) was the most frequent induction regimen administered in 91% of all patients. The rate of complete response (CR) in the SV group was 74%

CONCLUSIONS: Our results show that SV histology represents a poor risk group with lower CR rate and shorter PFS and this should be considered in the risk stratification of classical HL patients.

Keywords: Hodgkin lymphoma; nodular sclerosis; outcome; syncytial variant

Conflict of interest statement

TS, VN, SL, DM and JG have nothing to declare NR declares an interest in Celgene (research funding, advisory board); Seattle Genetics, Pharmacyclics, Gilead, AbbVie (advisory board). There are no dir

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